CAS 301692-76-2

Polmacoxib

Description:

Polmacoxib is a selective cyclooxygenase-2 (COX-2) inhibitor, primarily developed for its anti-inflammatory and analgesic properties. It belongs to the class of non-steroidal anti-inflammatory drugs (NSAIDs) and is characterized by its ability to reduce pain and inflammation by inhibiting the COX-2 enzyme, which plays a crucial role in the inflammatory process. Polmacoxib is notable for its improved gastrointestinal safety profile compared to traditional NSAIDs, making it a potential alternative for patients at risk of gastrointestinal complications. The compound exhibits a relatively high oral bioavailability and is metabolized in the liver, with its pharmacokinetics influenced by various factors such as dosage and individual patient characteristics. Its therapeutic applications primarily include the management of pain associated with conditions like osteoarthritis and rheumatoid arthritis. As with any medication, potential side effects may include cardiovascular risks and renal impairment, necessitating careful patient monitoring. Overall, Polmacoxib represents a significant advancement in the development of targeted anti-inflammatory therapies.

Formula: C₁₈H₁₆FNO₄S

InChI: InChI=1S/C18H16FNO4S/c1-18(2)17(21)15(12-4-3-5-13(19)10-12)16(24-18)11-6-8-14(9-7-11)25(20,22)23/h3-10H,1-2H3,(H2,20,22,23)

InChI key: InChIKey=IJWPAFMIFNSIGD-UHFFFAOYSA-N

SMILES: O=C1C(=C(OC1(C)C)C2=CC=C(S(N)(=O)=O)C=C2)C3=CC(F)=CC=C3

Synonyms:

• Acelex
• Benzenesulfonamide, 4-[3-(3-fluorophenyl)-4,5-dihydro-5,5-dimethyl-4-oxo-2-furanyl]-
• 4-[3-(3-Fluorophenyl)-4,5-dihydro-5,5-dimethyl-4-oxo-2-furanyl]benzenesulfonamide
• CG 100649
• Polmacoxib
• 5-{4-(aminosulfonyl)phenyl}-2,2-dimethyl-4-(3-fluorophenyl)-3(2H)-furanone
• 4-(3-(3-fluorophenyl)-5,5-dimethyl-4-oxo-4,5-dihydrofuran-2-yl)benzenesulfonamide
• 4-[3-(3-fluorophenyl)-5,5-diMethyl-4-oxo-4,5-dihydrofuran-2-yl]benzene-1-sulfonaMide

4-(3-(3-Fluorophenyl)-5,5-dimethyl-4-oxo-4,5-dihydrofuran-2-yl)benzenesulfonamide

CAS: 301692-76-2

Formula: C₁₈H₁₆FNO₄S

Purity: 97%

Color and Shape: Solid

Molecular weight: 361.3873

Ref: IN-DA00C40H

Polmacoxib

CAS: 301692-76-2

Formula: C₁₈H₁₆FNO₄S

Color and Shape: Pale Yellow Solid

Molecular weight: 361.39

Ref: 4Z-P-279001

Polmacoxib

CAS: 301692-76-2

Polmacoxib

Purity: ≥95%

Molecular weight: 361.39g/mol

Ref: 54-BUP09739

Polmacoxib

CAS: 301692-76-2

Polmacoxib, a first-class NSAID, dual inhibitor of CA and COX-2, may hinder colorectal cancer growth in mice.

Formula: C₁₈H₁₆FNO₄S

Purity: 97.88%

Color and Shape: Solid

Molecular weight: 361.39

Ref: TM-T21294

Polmacoxib

CAS: 301692-76-2

Polmacoxib is a non-steroidal anti-inflammatory drug (NSAID), which is derived through synthetic chemical processes. It functions as a selective cyclooxygenase-2 (COX-2) inhibitor. By selectively inhibiting the COX-2 enzyme, polmacoxib reduces the conversion of arachidonic acid to prostaglandins that mediate inflammation and pain, while sparing the COX-1 enzyme that protects gastric mucosa and maintains platelet function.

Formula: C₁₈H₁₆FNO₄S

Purity: Min. 95%

Color and Shape: Light (Or Pale) Yellow To Yellow Solid

Molecular weight: 361.07841

Ref: 3D-FP172578

Polmacoxib

Controlled Product

CAS: 301692-76-2

Formula: C₁₈H₁₆FNO₄S

Color and Shape: Neat

Molecular weight: 361.387

Ref: TR-P698950