CAS 3018834-98-2

7(8H)-Pteridinone, 8-[4-(difluoromethoxy)phenyl]-2-ethoxy-6-[2-(1-hydroxy-1-methylethyl)-1-methyl-1H-benzimidazol-6-yl]-

Description:

7(8H)-Pteridinone, 8-[4-(difluoromethoxy)phenyl]-2-ethoxy-6-[2-(1-hydroxy-1-methylethyl)-1-methyl-1H-benzimidazol-6-yl]- is a complex organic compound characterized by its pteridinone core structure, which is a bicyclic compound containing a pyrimidine and a pyridine ring. This substance features multiple functional groups, including an ethoxy group and a difluoromethoxy substituent, which contribute to its chemical reactivity and potential biological activity. The presence of a benzimidazole moiety suggests possible interactions with biological targets, making it of interest in medicinal chemistry. The compound's structure indicates it may exhibit properties such as solubility in organic solvents, potential for hydrogen bonding, and specific steric interactions due to its bulky substituents. The difluoromethoxy group may enhance lipophilicity, influencing its pharmacokinetic profile. Overall, this compound's unique structural features suggest it could have applications in drug development or as a biochemical probe, although specific biological activities would require further investigation.

Formula: C₂₆H₂₄F₂N₆O₄

Synonyms:

• 7(8H)-Pteridinone, 8-[4-(difluoromethoxy)phenyl]-2-ethoxy-6-[2-(1-hydroxy-1-methylethyl)-1-methyl-1H-benzimidazol-6-yl]-

MAT2A-IN-20

CAS: 3018834-98-2

MAT2A-IN-20 (Compound A49) is an inhibitor of methionine adenosyltransferase 2A (MAT2A) with an IC50 of ≤50 nM. It also inhibits human UGT1A1 with an IC50 of 28.45 μM. Additionally, MAT2A-IN-20 exhibits antitumor activity in mouse models.

Formula: C₂₆H₂₄F₂N₆O₄

Color and Shape: Solid

Molecular weight: 522.503

Ref: TM-T204278