CAS 302-91-0

5α-Tetrahydrocortisol

Description:

5α-Tetrahydrocortisol, with the CAS number 302-91-0, is a steroid hormone that is a metabolite of cortisol, which is a glucocorticoid produced by the adrenal cortex. This compound is characterized by its structure, which includes a steroid nucleus with specific functional groups that contribute to its biological activity. It is known for its role in the metabolism of carbohydrates, proteins, and fats, as well as its involvement in the regulation of immune responses and stress reactions. 5α-Tetrahydrocortisol exhibits anti-inflammatory properties and can influence various physiological processes. In terms of solubility, it is generally lipophilic, allowing it to easily cross cell membranes and interact with intracellular receptors. The compound is often studied in the context of adrenal function and disorders related to cortisol metabolism. Its presence can be detected in biological fluids, making it relevant in clinical and research settings for understanding hormonal balance and related health conditions.

Formula: C₂₁H₃₄O₅

InChI: InChI=1S/C21H34O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h12-16,18,22-24,26H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18+,19-,20-,21-/m0/s1

InChI key: InChIKey=AODPIQQILQLWGS-FDSHTENPSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@@](CC3)(C[C@H](O)CC4)[H])([C@@H](O)C1)[H])[H])(CC[C@@]2(C(CO)=O)O)[H]

Synonyms:

• (3Alpha,5Alpha,11Beta)-3,11,17,21-Tetrahydroxypregnan-20-One
• (3α,5α,11β)-3,11,17,21-Tetrahydroxypregnan-20-one
• 3-Alpha,11-Beta,17-Alpha,21-Tetrahydroxy-5-Alpha-Pregnan-20-One
• 3α,11β,17,21-Tetrahydroxy-5α-pregnan-20-one
• 3α,11β,17α,21-Tetrahydroxy-5α-pregnan-20-one
• 3α,5α-Tetrahydrocortisol
• 5α-Pregnan-20-one, 3α,11β,17,21-tetrahydroxy-
• 5α-Pregnane-3α,11β,17α,21-tetraol-20-one
• 5α-THF
• 5α-Tetrahydrocortisol
• Al 3308
• Allo-3α-tetrahydrocortisol
• Allopregnane-3α,11β,17α,21-tetrol-20-one
• Allotetrahydrocompound F
• Allotetrahydrocortisol
• Cortisol, allotetrahydro-
• Kendall's compound C
• NSC 86469
• Pregnan-20-one, 3,11,17,21-tetrahydroxy-, (3α,5α,11β)-
• Reichstein's substance C
• Wintersteiner's compound D
• allo-Tetrahydrocortisol

Allotetrahydrocortisol

CAS: 302-91-0

Allotetrahydrocortisol (5a-Tetrahydrocortisol) is a metabolite of Cortisol. Cortisol is the main glucocorticoid in human.

Formula: C₂₁H₃₄O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 366.49

Ref: TM-T13517

Allo-3α-tetrahydro Cortisol

Controlled Product

CAS: 302-91-0

Stability Hygroscopic
Applications A metabolite of Cortisol (H714615).
References Quinkler, M., et al.: J. Clin. Endocrinol. Metab., 88, 2384 (2003), Draper, N., et al.: J. Endocrinol., 186, 251 (2005), Kotlowska, A., et al.: Clin. Biochem., 42, 448 (2009),

Formula: C₂₁H₃₄O₅

Color and Shape: Off White Solid

Molecular weight: 366.49

Ref: TR-A548500

Allo-3a-tetrahydro cortisol

Controlled Product

CAS: 302-91-0

Allo-3a-tetrahydro cortisol (ATHC) is a synthetic form of the hormone cortisol that has been modified to be more stable in vivo. It can be used to supplement cortisol levels when the body does not produce enough on its own or when there is an adrenal tumor or other cause for low cortisol production. ATHC has been shown to have anti-inflammatory and anti-cancer properties, as well as reduce body mass index, lower blood pressure, and improve symptoms of chronic fatigue syndrome. This drug also increases glomerular filtration rate and was found to be safe in clinical trials. However, ATHC should not be administered with estradiol benzoate due to the risk of liver damage.

Formula: C₂₁H₃₄O₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 366.49 g/mol

Ref: 3D-FA17285

Allo-3a-tetrahydro Cortisol-d6 (Major)

Controlled Product

CAS: 302-91-0

Formula: C₂₁H₂₈D₆O₅

Color and Shape: Neat

Molecular weight: 372.52863

Ref: TR-A548502