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CAS 3020690-76-7

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  • HDM-IN-1
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    HDM-IN-1

    CAS:
    HDM-IN-1 (Compound A4) is an inhibitor of fungal histone demethylase (HDM) that inhibits H3K27me3 in Cryptococcus neoformans and Candida auris, with IC50 values of 134 nM and 12 nM, respectively. It demonstrates inhibitory activity against these fungi by preventing biofilm and capsule formation, with an MIC80 of 0.5-2 μg/mL. Additionally, HDM-IN-1 exhibits antifungal activity in ICR mouse models.
    Formula:C17H15N5O
    Color and Shape:Solid
    Molecular weight:305.33

    Ref: TM-T203574

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