PROTAC STING Degrader-2 is a chemical compound designed as a targeted protein degradation agent, specifically aimed at modulating the activity of the stimulator of interferon genes (STING) pathway. This compound belongs to a class of molecules known as PROTACs (proteolysis-targeting chimeras), which harness the cellular ubiquitin-proteasome system to selectively degrade specific proteins. The characteristics of PROTAC STING Degrader-2 include its ability to bind to both the target protein and an E3 ubiquitin ligase, facilitating the ubiquitination and subsequent degradation of the target protein. This mechanism allows for precise control over protein levels within cells, making it a valuable tool in therapeutic applications, particularly in cancer and autoimmune diseases where STING signaling plays a critical role. Additionally, the compound's design may include features that enhance its bioavailability, stability, and selectivity, although specific physicochemical properties such as solubility, melting point, and molecular weight would require empirical data for detailed characterization.

PROTAC STING Degrader-2

3023095-61-3: PROTAC STING Degrader-2 is a chemical compound designed as a targeted protein degradation agent, specifically aimed at modulating the activity of the stimulator of interferon genes (STING) pathway. This compound belongs to a class of molecules known as PROTACs (proteolysis-targeting chimeras), which harness the cellular ubiquitin-proteasome system to selectively degrade specific proteins. The characteristics of PROTAC STING Degrader-2 include its ability to bind to both the target protein and an E3 ubiquitin ligase, facilitating the ubiquitination and subsequent degradation of the target protein. This mechanism allows for precise control over protein levels within cells, making it a valuable tool in therapeutic applications, particularly in cancer and autoimmune diseases where STING signaling plays a critical role. Additionally, the compound's design may include features that enhance its bioavailability, stability, and selectivity, although specific physicochemical properties such as solubility, melting point, and molecular weight would require empirical data for detailed characterization.

<p>PROTAC STING Degrader-2 is a protein degrader targeting the Stimulator of interferon genes (STING) with a DC50 of 0.53 μM. It induces STING protein degradation by covalently binding to both the STING protein and an E3 ubiquitin ligase. This compound is useful for studying the role of STING in autoinflammatory and autoimmune diseases.</p>

CAS 3023095-61-3

PROTAC STING Degrader-2

PROTAC STING Degrader-2

Ref: TM-T88066