CAS 30246-33-4

(6R-trans)-7-amino-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Description:

The chemical substance known as (6R-trans)-7-amino-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, with the CAS number 30246-33-4, is a synthetic compound that belongs to the class of antibiotics. It features a bicyclic structure, which is characteristic of certain beta-lactam antibiotics, and contains a thiadiazole moiety that contributes to its biological activity. The presence of an amino group and a carboxylic acid functional group suggests potential interactions with biological targets, enhancing its pharmacological properties. This compound is known for its antibacterial activity, particularly against a range of Gram-positive and Gram-negative bacteria. Its unique structural features may also influence its solubility, stability, and mechanism of action. As with many antibiotics, understanding its characteristics is crucial for evaluating its therapeutic potential and safety profile in clinical applications.

Formula: C₁₁H₁₂N₄O₃S₃

InChI: InChI=1/C11H12N4O3S3/c1-4-13-14-11(21-4)20-3-5-2-19-9-6(12)8(16)15(9)7(5)10(17)18/h6,9H,2-3,12H2,1H3,(H,17,18)/t6-,9-/m0/s1

InChI key: InChIKey=HJSGHKMSDOLGJJ-HZGVNTEJSA-N

SMILES: C(O)(=O)C=1N2[C@@]([C@H](N)C2=O)(SCC1CSC=3SC(C)=NN3)[H]

Synonyms:

• (6R,7R)-7-Amino-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• (6S,7S)-7-ammonio-3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• (7R)-7-amino-3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-amino-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-amino-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-, (6R,7R)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-amino-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-, (6R-trans)-
• 7-Amino-3-(5-methyl-1,3,4-thiadiazol-2-ylthiomethyl)-δ-3-cephem-4-carboxylic acid
• 7-Amino-3-[(2-methyl-1,3,4-thiadiazol-5-ylthio)methyl]-3-cephem-4-carboxylic acid
• 7-Amino-3-[(5-Methyl-1,3,4-Thiadiazol-2-Yl)Thiomethyl]Cephalosphoranic Acid
• 7-Amino-3-[(5-methyl-1,3,4-thiadiazol-2-ylthio)methyl]-3-cephem-4-carboxylic acid
• 7-Tda
• 7-Zaca
• Parent nucleus of cefazedone
• (6R-trans)-7-Amino-3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid
• Cefazolin EP Impurity A
• Cefuroxime nucleus (7-TDA)
• (7r)-7-amino-3-[(5-methyl-1,3,4-thiadiazol-2-yl)thiomethyl]-3-cephem-4-carboxylicacid
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 7-amino-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-, (6R,7R)-
• Parent nucleus of cefazedone (7-TDA)
• Cefazolin Impurity 7(Cefazolin EP Impurity A)
• Cefazolin USP Impurity K
• TDA
• 3,5-Dichloro-4-hydroxypyridine，7-Amino-3-[(5-methyl-1,3,4-thiadiazol- 2-ylthio)methyl]-3-cephem-4- carboxylic Acid
• Cefazolin Impurity EP-A
• 7-Amino-3-[[(5-methyl-1,3,4-thiadiazol-2yl)thiomethyl]-3-cephalosporanicacid
• 7-Amino-3-[(5-methyl-1,3,4-thiadiazol-2-yl)-thiomethyl]-cephalosporanic aci
• 7-ammonio-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• Cefazolin IMpurity A
• (6R)-7α-Amino-3-(5-methyl-1,3,4-thiadiazol-2-ylthiomethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• Cefazolin Sodium Impurity A
• (6R,7R)-7-amino-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• 7-Amino-3-([5-methyl-1,3,4-thiadiazol-2-yl] thiomethyl)-3-cephem-4-carboxylic acid

7-Amino-3-[(5-Methyl-1,3,4-Thiadiazol-2-Yl)Thiomethyl]Cephalosphoranic Acid

CAS: 30246-33-4

Formula: C₁₁H₁₂N₄O₃S₃

Purity: 99%

Color and Shape: Solid

Molecular weight: 344.4330

Ref: IN-DA00BDYC

Cefazolin EP Impurity A

CAS: 30246-33-4

Formula: C₁₁H₁₂N₄O₃S₃

Color and Shape: White To Off-White Solid

Molecular weight: 344.44

Ref: 4Z-C-9611

7-Amino-3-[(5-Methyl-1,3,4-Thiadiazol-2-yl)Thiomethyl]Cephalosphoranic Acid

CAS: 30246-33-4

7-Amino-3-[(5-Methyl-1,3,4-Thiadiazol-2-yl)Thiomethyl]Cephalosphoranic Acid

Purity: 99%

Molecular weight: 344.44g/mol

Ref: 54-OR1012052

7-ZACA

CAS: 30246-33-4

7-ZACA (cefazolin decarboxylated) is a decarboxylated derivative of cefazolin.

Formula: C₁₁H₁₂N₄O₃S₃

Purity: 99.73%

Color and Shape: Solid

Molecular weight: 344.42

Ref: TM-T66940

7-Amino-3-[(5-methyl-1,3,4-thiadiazol-2-ylthio)methyl]-3-cephem-4-carboxylic Acid

Controlled Product

CAS: 30246-33-4

Impurity Cefazolin EP Impurity A
Applications 7-Amino-3-[(5-methyl-1,3,4-thiadiazol-2-ylthio)methyl]-3-cephem-4-carboxylic Acid (Cefazolin EP Impurity A) is a substrate used in the assessment of immobilized PGA orientation and in the synthesis of beta lactam antibiotics.
References Serra, I. et al.: Anal. Bioanal. Chem., 405, 745 (2013); Terreni, M. et al.: App. Microbiol. Biotech., 77, 579 (2007); Kurochkina, V. et al.: Biocat. Biotransform., 20, 35 (2002)

Formula: C₁₁H₁₂N₄O₃S₃

Color and Shape: Neat

Molecular weight: 344.43

Ref: TR-A618190

(6R,7R)-7-Amino-3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

CAS: 30246-33-4

Purity: 97.0%

Molecular weight: 344.4200134277344

Ref: 10-F546079

Cefazolin impurity A

CAS: 30246-33-4

Cefazolin impurity A is a by-product in the synthesis of Cefazolin, which is a drug product. It has CAS No. 30246-33-4 and is used as an impurity standard for analytical purposes. The Impurity Standard is also known as Metabolite A. Research and Development (R&D) studies are needed to identify the appropriate analytical impurities for this API, which will be reported on Pharmacopoeia's List of Impurities for reference. The high purity and custom synthesis of this API makes it ideal for use in R&D studies, HPLC standards, or niche markets.
CAS No.: 30246-33-4
Synonyms: Metabolite A
Formula: C11H14N2O5S
Molecular weight: 289.24 g/mol
Appearance: white solid powder

Formula: C₁₁H₁₂N₄O₃S₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 344.44 g/mol

Ref: 3D-IC63651

Cefazolin EP Impurity A

CAS: 30246-33-4

Formula: C₁₁H₁₂N₄O₃S₃

Molecular weight: 344.42

Ref: ST-EA-CP-C149001