Nrf2 degrader 1, identified by its CAS number 3025286-00-1, is a small molecule designed to selectively target and promote the degradation of the Nrf2 protein, a key regulator of cellular antioxidant responses. This compound is part of a class of molecules known as PROTACs (proteolysis-targeting chimeras), which harness the ubiquitin-proteasome system to eliminate specific proteins within cells. Nrf2 plays a crucial role in protecting cells from oxidative stress and inflammation, and its dysregulation is associated with various diseases, including cancer and neurodegenerative disorders. By degrading Nrf2, this compound can potentially modulate cellular responses to oxidative stress, making it a valuable tool for research into therapeutic strategies aimed at diseases where Nrf2 is implicated. The development of Nrf2 degrader 1 reflects a growing interest in targeted protein degradation as a novel approach in drug discovery and development, offering insights into the manipulation of cellular pathways for therapeutic benefit.

Nrf2 degrader 1

3025286-00-1: Nrf2 degrader 1, identified by its CAS number 3025286-00-1, is a small molecule designed to selectively target and promote the degradation of the Nrf2 protein, a key regulator of cellular antioxidant responses. This compound is part of a class of molecules known as PROTACs (proteolysis-targeting chimeras), which harness the ubiquitin-proteasome system to eliminate specific proteins within cells. Nrf2 plays a crucial role in protecting cells from oxidative stress and inflammation, and its dysregulation is associated with various diseases, including cancer and neurodegenerative disorders. By degrading Nrf2, this compound can potentially modulate cellular responses to oxidative stress, making it a valuable tool for research into therapeutic strategies aimed at diseases where Nrf2 is implicated. The development of Nrf2 degrader 1 reflects a growing interest in targeted protein degradation as a novel approach in drug discovery and development, offering insights into the manipulation of cellular pathways for therapeutic benefit.

<p>Nrf2 degrader 1 (compound 1), a PROTAC Nrf2 degrader, exhibits anticancer properties by inhibiting the growth of cancer cells. It demonstrates IC 50 values of 100 nM for A549 cells and 40 nM for LK-2 cells, indicating potent efficacy [1].</p>

CAS 3025286-00-1

Nrf2 degrader 1

Nrf2 degrader 1

Ref: TM-T87036