PROTAC ERα Degrader-7 is a chemical compound designed as a targeted protein degradation agent, specifically aimed at the estrogen receptor alpha (ERα). This compound belongs to a class of molecules known as PROTACs (Proteolysis Targeting Chimeras), which utilize the cellular ubiquitin-proteasome system to selectively degrade specific proteins. The structure of PROTAC ERα Degrader-7 typically includes a ligand that binds to ERα and another that recruits an E3 ubiquitin ligase, facilitating the ubiquitination and subsequent degradation of the target protein. This mechanism allows for the modulation of protein levels in a highly selective manner, making it a promising tool in therapeutic applications, particularly in hormone-dependent cancers. The compound's efficacy and specificity are influenced by its chemical structure, which can be optimized for improved performance. As a research tool, PROTAC ERα Degrader-7 contributes to the understanding of protein function and the development of novel therapeutic strategies in oncology and other fields.

PROTAC ERα Degrader-7

3025781-93-2: PROTAC ERα Degrader-7 is a chemical compound designed as a targeted protein degradation agent, specifically aimed at the estrogen receptor alpha (ERα). This compound belongs to a class of molecules known as PROTACs (Proteolysis Targeting Chimeras), which utilize the cellular ubiquitin-proteasome system to selectively degrade specific proteins. The structure of PROTAC ERα Degrader-7 typically includes a ligand that binds to ERα and another that recruits an E3 ubiquitin ligase, facilitating the ubiquitination and subsequent degradation of the target protein. This mechanism allows for the modulation of protein levels in a highly selective manner, making it a promising tool in therapeutic applications, particularly in hormone-dependent cancers. The compound's efficacy and specificity are influenced by its chemical structure, which can be optimized for improved performance. As a research tool, PROTAC ERα Degrader-7 contributes to the understanding of protein function and the development of novel therapeutic strategies in oncology and other fields.

<p>PROTAC ERα Degrader-7 (Compound i-320) is a powerful PROTAC degrader targeting the estrogen receptor alpha (ERα), exhibiting a DC50 of 0.000006 µM. This compound consists of a cereblon-binding segment, LBM, connected to ERBM, an ERα-binding ligand that includes a benzofused partially saturated 6-membered carbocyclic or heterocyclic ring [1].</p>

CAS 3025781-93-2

PROTAC ERα Degrader-7

PROTAC ERα Degrader-7

Ref: TM-T87264