CAS 3025799-28-1

Pyrrolo[1,2-a]pyrazine-8-carboxamide, 6-[4-[(2-fluoro-1-oxo-2-propen-1-yl)amino]phenyl]-3-methyl-7-[4-[(4-methyl-2-pyrimidinyl)oxy]phenyl]-

Description:

Pyrrolo[1,2-a]pyrazine-8-carboxamide, 6-[4-[(2-fluoro-1-oxo-2-propen-1-yl)amino]phenyl]-3-methyl-7-[4-[(4-methyl-2-pyrimidinyl)oxy]phenyl]- is a complex organic compound characterized by its unique bicyclic structure, which includes a pyrrolo[1,2-a]pyrazine core. This compound features multiple functional groups, including a carboxamide and various aromatic substituents, which contribute to its potential biological activity. The presence of a fluoro group and a propenyl moiety suggests that it may exhibit interesting reactivity and pharmacological properties. The compound's molecular structure indicates potential interactions with biological targets, making it a candidate for research in medicinal chemistry. Its specific CAS number, 3025799-28-1, allows for precise identification and retrieval of information regarding its synthesis, properties, and applications in scientific literature. Overall, this compound exemplifies the complexity and diversity of modern organic molecules, particularly in the context of drug discovery and development.

Formula: C₂₉H₂₃FN₆O₃

Synonyms:

• FGFR2/3-IN-2
• Pyrrolo[1,2-a]pyrazine-8-carboxamide, 6-[4-[(2-fluoro-1-oxo-2-propen-1-yl)amino]phenyl]-3-methyl-7-[4-[(4-methyl-2-pyrimidinyl)oxy]phenyl]-

FGFR2/3-IN-2

CAS: 3025799-28-1

FGFR2/3-IN-2 (compound 10) is an orally active inhibitor targeting FGFR2 and FGFR3. It exhibits IC50 values of 3.7 nM for FGFR2 and 31.2 nM for FGFR3, with a pre-incubation time of 1 hour. FGFR2/3-IN-2 demonstrates selectivity over FGFR1/4 and other kinases, and does not cause diarrhea or increased serum phosphate in vivo. In the SNU-16 gastric cancer model, FGFR2/3-IN-2 can induce tumor stasis or regression.

Formula: C₂₉H₂₃FN₆O₃

Color and Shape: Solid

Molecular weight: 522.53

Ref: TM-T205706