CAS 30271-38-6

24-Hydroxycholesterol

CAS: 30271-38-6

24-Hydroxycholesterol (Cholest-5-ene-3beta,24-diol) is an activator of the LXR and can be used to study cardiogenesis and pancreatic cancer.

Formula: C₂₇H₄₆O₂

Purity: 99.8%

Color and Shape: Solid

Molecular weight: 402.65

Ref: TM-T10086

24-Hydroxycholesterol-d4

Controlled Product

CAS: 30271-38-6

Applications Isotope labelled 24-Hydroxycholesterol is the main cholesterol elimination product of the brain and was found to be increased in serum of Alzheimer patients.
References Kolsch, H., et al.: J. Neural. Transm., 108, 475 (2001); Gamba, P., et al.: Aging. Cell., 10, 403 (2011); Seet, R.C.S., et al.: Free. Rad. Biol. Med., 48, 560 (2010);

Formula: C₂₇H₄₂D₄O₂

Color and Shape: Neat

Molecular weight: 406.68

Ref: TR-H918042

24-Hydroxycholesterol

Controlled Product

CAS: 30271-38-6

Applications 24-Hydroxycholesterol is the main cholesterol elimination product of the brain and was found to be increased in serum of Alzheimer patients.
References Kolsch, H., et al.: J. Neural. Transm., 108, 475 (2001); Gamba, P., et al.: Aging. Cell., 10, 403 (2011); Seet, R.C.S., et al.: Free. Rad. Biol. Med., 48, 560 (2010);

Formula: C₂₇H₄₆O₂

Color and Shape: Neat

Molecular weight: 402.65

Ref: TR-H918040

24-Hydroxycholesterol

Controlled Product

CAS: 30271-38-6

24-Hydroxycholesterol is a metabolite of cholesterol that can be found in the blood and urine. It has been studied for its role in x-linked adrenoleukodystrophy (XALD), which is a genetic disorder that affects the nervous system and the brain. Studies have shown that 24-hydroxycholesterol may regulate gene transcription by binding to specific antibodies. This substance also has significant cytotoxicity, which may be due to its hydroxyl group, and has been shown to protect neurons from cell death in rats. The major cause of XALD is mutations on the ABCD1 gene, which encodes for an enzyme responsible for breaking down 24-hydroxycholesterol. A diagnosis of XALD can be done using 24-hydroxycholesterol levels in urine samples.

Formula: C₂₇H₄₆O₂

Purity: Min. 95%

Molecular weight: 402.65 g/mol

Ref: 3D-FBA27138