CAS 302962-49-8
:Dasatinib
Description:
Dasatinib is a small molecule tyrosine kinase inhibitor primarily used in the treatment of certain types of leukemia, particularly chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL). Its chemical formula is C22H26ClN5O2S, and it features a complex structure that includes a 2-aminopyrimidine core, a thiazole ring, and a chlorophenyl group. Dasatinib works by inhibiting the activity of BCR-ABL, a fusion protein that drives the proliferation of cancer cells in CML, as well as other tyrosine kinases involved in cell signaling pathways. The drug is known for its ability to overcome resistance to other treatments, making it a valuable option in targeted cancer therapy. Dasatinib is typically administered orally and is characterized by its relatively high bioavailability. Common side effects may include gastrointestinal disturbances, fatigue, and hematological abnormalities. As with any medication, its use should be closely monitored by healthcare professionals to manage potential adverse effects and interactions with other drugs.
Formula:C22H26ClN7O2S
InChI:InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)
InChI key:InChIKey=ZBNZXTGUTAYRHI-UHFFFAOYSA-N
SMILES:N(C1=CC(N2CCN(CCO)CC2)=NC(C)=N1)C=3SC(C(NC4=C(C)C=CC=C4Cl)=O)=CN3
Synonyms:- 5-Thiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-
- Bms 345825
- Bms 354825
- Bms 35482513
- Intermediate
- Kin 001-5
- N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide
- N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide
- N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide hydrate (1:1)
- NSC 759877
- Sprycel
- Spyrcel
- See more synonyms
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Found 10 products.
Dasatinib
CAS:Formula:C22H26ClN7O2SPurity:>95.0%(T)(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:488.01Dasatinib
CAS:<p>Dasatinib (BMS-354825) is a tyrosine kinase inhibitor that inhibits Src and Bcr-Abl (Ki=16/30 pM) and is orally active and ATP-competitive.</p>Formula:C22H26ClN7O2SPurity:99.59% - 99.86%Color and Shape:Pale-Yellow SolidMolecular weight:488.01N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide
CAS:Formula:C22H26ClN7O2SPurity:98%Color and Shape:SolidMolecular weight:488.0055Dasatinib
CAS:Formula:C22H26ClN7O2SPurity:≥ 98.0%Color and Shape:White to beige powderMolecular weight:488.01Dasatinib
CAS:<p>Inhibits SRC-family of tyrosine kinases</p>Formula:C22H26ClN7O2SPurity:Min. 98 Area-%Color and Shape:White PowderMolecular weight:488.01 g/molDasatinib - Bio-X ™
CAS:<p>Dasatinib is a potent inhibitor of tyrosine kinases and is used in the treatment of chronic myelogenous leukemia, gastrointestinal stromal tumors, and other types of cancer. It also inhibits many SRC- family kinases. Dasatinib has been shown to inhibit the proliferation of cancer cells, leading to cell lysis. Additionally, it has anti-angiogenic effects in vivo, inhibiting the development of new blood vessels in solid tumours.</p>Formula:C22H26ClN7O2SPurity:Min. 95%Color and Shape:PowderMolecular weight:488.01 g/mol
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