CAS 302962-49-8: Dasatinib

Description: Dasatinib is a small molecule tyrosine kinase inhibitor primarily used in the treatment of certain types of leukemia, particularly chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL). Its chemical formula is C22H26ClN5O2S, and it features a complex structure that includes a 2-aminopyrimidine core, a thiazole ring, and a chlorophenyl group. Dasatinib works by inhibiting the activity of BCR-ABL, a fusion protein that drives the proliferation of cancer cells in CML, as well as other tyrosine kinases involved in cell signaling pathways. The drug is known for its ability to overcome resistance to other treatments, making it a valuable option in targeted cancer therapy. Dasatinib is typically administered orally and is characterized by its relatively high bioavailability. Common side effects may include gastrointestinal disturbances, fatigue, and hematological abnormalities. As with any medication, its use should be closely monitored by healthcare professionals to manage potential adverse effects and interactions with other drugs.

Formula: C₂₂H₂₆ClN₇O₂S

InChI: InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)

InChI key: InChIKey=ZBNZXTGUTAYRHI-UHFFFAOYSA-N

SMILES: O=C(NC=1C(Cl)=CC=CC1C)C=2SC(=NC2)NC=3N=C(N=C(C3)N4CCN(CCO)CC4)C

Synonyms:

• 5-Thiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-
• Bms 345825
• Bms 354825
• Bms 35482513
• Intermediate
• Kin 001-5
• N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide
• N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide
• N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide hydrate (1:1)
• NSC 759877
• Sprycel
• Spyrcel
• Dasatinib

Dasatinib

CAS: 302962-49-8

• Formula: C₂₂H₂₆ClN₇O₂S
• Purity: >95.0%(T)(HPLC)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 488.01

Dasatinib

CAS: 302962-49-8

Dasatinib (BMS-354825) is a tyrosine kinase inhibitor that inhibits Src and Bcr-Abl (Ki=16/30 pM) and …

• Formula: C₂₂H₂₆ClN₇O₂S
• Purity: 99.59% - 99.86%
• Color and Shape: Pale-Yellow Solid
• Molecular weight: 488.01

5-Thiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-

CAS: 302962-49-8

• Formula: C₂₂H₂₆ClN₇O₂S
• Purity: 95%
• Color and Shape: Solid
• Molecular weight: 488.0055

Dasatinib

CAS: 302962-49-8

• Formula: C₂₂H₂₆ClN₇O₂S
• Color and Shape: White To Off-White Solid
• Molecular weight: 488.01

Dasatinib

CAS: 302962-49-8

• Formula: C₂₂H₂₆ClN₇O₂S
• Purity: ≥ 98.0%
• Color and Shape: White to beige powder
• Molecular weight: 488.01

Dasatinib

CAS: 302962-49-8

• Formula: C₂₂H₂₆ClN₇O₂S
• Color and Shape: White To Off-White
• Molecular weight: 488.01

Dasatinib

CAS: 302962-49-8

• Purity: 95.0%
• Color and Shape: Solid
• Molecular weight: 488.010009765625

Dasatinib

CAS: 302962-49-8

Inhibits SRC-family of tyrosine kinases

• Formula: C₂₂H₂₆ClN₇O₂S
• Purity: Min. 98 Area-%
• Color and Shape: White Powder
• Molecular weight: 488.01 g/mol

Dasatinib - Bio-X ™

CAS: 302962-49-8

Dasatinib is a potent inhibitor of tyrosine kinases and is used in the treatment of …

• Formula: C₂₂H₂₆ClN₇O₂S
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 488.01 g/mol