CAS 30299-08-2

clinofibrate

Description:

Clinofibrate is a synthetic compound classified as a fibrate, primarily used for its lipid-lowering properties. It is known to enhance the metabolism of lipids, particularly triglycerides, and is often employed in the management of dyslipidemia. Clinofibrate functions by activating peroxisome proliferator-activated receptors (PPARs), which play a crucial role in fatty acid oxidation and lipid metabolism. The substance is typically presented as a white to off-white crystalline powder, exhibiting low solubility in water but higher solubility in organic solvents. Its chemical structure includes a phenyl group and a carboxylic acid moiety, contributing to its biological activity. Clinofibrate has been studied for its potential effects on cardiovascular health, although its clinical use has diminished with the advent of newer lipid-modifying agents. Safety profiles indicate that it may cause gastrointestinal disturbances and other side effects, necessitating careful monitoring during therapy. Overall, clinofibrate represents an important compound in the context of lipid management, although its application is less common in contemporary clinical practice.

Formula: C₂₈H₃₆O₆

InChI: InChI=1/C28H36O6/c1-5-26(3,24(29)30)33-22-14-10-20(11-15-22)28(18-8-7-9-19-28)21-12-16-23(17-13-21)34-27(4,6-2)25(31)32/h10-17H,5-9,18-19H2,1-4H3,(H,29,30)(H,31,32)

InChI key: InChIKey=BMOVQUBVGICXQN-UHFFFAOYSA-N

SMILES: O(C(C(O)=O)(CC)C)C1=CC=C(C2(CCCCC2)C3=CC=C(OC(C(O)=O)(CC)C)C=C3)C=C1

Synonyms:

• 1,1-Bis[4'-(1''-carboxy-1''-methylpropoxy)phenyl]cyclohexane
• 2,2'-(Cyclohexylidenebis(4,1-Phenyleneoxy))Bis(2-Methyl)-Butanoic Acid
• 2,2'-[Cyclohexane-1,1-Diylbis(Benzene-4,1-Diyloxy)]Bis(2-Methylbutanoic Acid)
• 2,2’-(4,4’-Cyclohexylidenediphenoxy)-2,2’-Dimethyldibutyricacid
• 2,2’-Cyclohexane-1,1-Diylbis(P-Phenyleneoxy)Bis(2-Methylbutyricacid)
• 2,2’-Cyclohexane-1,1-Diylbis(P-Phenyleneoxy)Bis-(2-Methyl-Butyricaci
• 2,2′-[Cyclohexylidenebis(4,1-phenyleneoxy)]bis[2-methylbutanoic acid]
• Butanoic acid, 2,2′-[cyclohexylidenebis(4,1-phenyleneoxy)]bis[2-methyl-
• Clinofibrate(Forr&Donly)
• Lipoclin
• S 8527
• Clinofibrate
• 2,2'-[Cyclohexylidenebis(4,1-phenyleneoxy)]bis(2-methylbutyric acid)

Butanoic acid, 2,2'-[cyclohexylidenebis(4,1-phenyleneoxy)]bis[2-methyl-

CAS: 30299-08-2

Formula: C₂₈H₃₆O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 468.5818

Ref: IN-DA002ZJP

Clinofibrate

CAS: 30299-08-2

Formula: C₂₈H₃₆O₆

Color and Shape: White To Off-White Solid

Molecular weight: 468.60

Ref: 4Z-C-199001

2,2’-((Cyclohexane-1,1-Diylbis(4,1-Phenylene))Bis(Oxy))Bis(2-Methylbutanoic Acid)

CAS: 30299-08-2

2,2’-((Cyclohexane-1,1-Diylbis(4,1-Phenylene))Bis(Oxy))Bis(2-Methylbutanoic Acid)

Purity: 98%

Molecular weight: 468.58g/mol

Ref: 54-OR1009895

Clinofibrate

CAS: 30299-08-2

Clinofibrate

Purity: ≥98%

Molecular weight: 468.58g/mol

Ref: 54-BUP10702

Clinofibrate

CAS: 30299-08-2

Clinofibrate lowers lipids, blocks HMGCR (IC50: 0.47 mM), and controls cholesterol/triacylglycerides.

Formula: C₂₈H₃₆O₆

Purity: >99.99%

Color and Shape: White Crystalline Powder

Molecular weight: 468.58

Ref: TM-T6450

Clinofibrate

Controlled Product

CAS: 30299-08-2

Applications An antilipemic, used as an anti-atherosclerosis agent
References Cercos-Del-Pozo, R., et al.: J. Pharm. Pharmacol., 48, 240 (1996), Tomiyama, N., et al.: Clin. Exper. Pharmacol. Physiol., 34, 876 (2007),

Formula: C₂₈H₃₆O₆

Color and Shape: Neat

Molecular weight: 468.58

Ref: TR-C580100

CLINOFIBRATE

CAS: 30299-08-2

Purity: ≥98%

Molecular weight: 468.5899963

Ref: 10-F799449

Clinofibrate

CAS: 30299-08-2

Formula: C₂₈H₃₆O₆

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 468.59

Ref: 3B-C3100