CAS 303-26-4

Norchlorcyclizine

Description:

Norchlorcyclizine, with the CAS number 303-26-4, is a chemical compound that belongs to the class of antihistamines. It is a derivative of cyclizine, which is primarily used for its antiemetic and antihistaminic properties. Norchlorcyclizine exhibits a range of pharmacological effects, including the ability to alleviate symptoms associated with motion sickness and allergies. The compound is characterized by its structural features, which include a piperazine ring and a chlorinated aromatic system, contributing to its biological activity. It is typically administered in various formulations, and its efficacy is attributed to its ability to block histamine H1 receptors. Additionally, Norchlorcyclizine may have sedative effects, making it useful in certain therapeutic contexts. However, like many antihistamines, it may also cause side effects such as drowsiness, dry mouth, and dizziness. Its safety profile and pharmacokinetics are important considerations in clinical use, and it is essential to adhere to recommended dosages to minimize adverse effects.

Formula: C₁₇H₁₉ClN₂

InChI: InChI=1/C17H19ClN2/c18-16-8-6-15(7-9-16)17(14-4-2-1-3-5-14)20-12-10-19-11-13-20/h1-9,17,19H,10-13H2/p+2/t17-/m0/s1

InChI key: InChIKey=UZKBSZSTDQSMDR-UHFFFAOYSA-N

SMILES: C(C1=CC=C(Cl)C=C1)(C2=CC=CC=C2)N3CCNCC3

Synonyms:

• (±)-1-(p-Chlorobenzhydryl)piperazine
• 1-(4-Chloro-α-phenylbenzyl)piperazine
• 1-(4-Chlorobenzhydryl)-piperizine
• 1-(4-Chlorophenylmethyl)piperazine
• 1-(α-Phenyl-4-chlorobenzyl)piperazine
• 1-[(4-Chlorophenyl) phenylmethyl] piperazine
• 1-[(R)-(4-chlorophenyl)(phenyl)methyl]piperazinediium
• 1-[(S)-(4-chlorophenyl)(phenyl)methyl]piperazinediium
• 1-[4-Chlorophenyl) (Phenyl)Methyl] Piperazine
• 4-(4-Chlorobenzhydryl)piperazine
• Chlorophenyl)(phenyl)methyl)piperazine,1-((4-
• N-(4-Chlorobenzhydryl)piperazine
• N-(4-Chlorophenyl)phenylmethylpiperazine
• N-(p-Chlorobenzhydryl)-piperazine
• NSC 86164
• Norchlorcyclizine
• Piperazine, 1-(p-chloro-α-phenylbenzyl)-
• Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-
• N-(4-CHLOROBENZYLHYDRYL)PIPERAZINE
• Piperazine, 1-(p-chloro-alpha-phenylbenzyl)-
• 1-((4-chlorophenyl)phenylmethyl)-piperazin
• 1-(4-Chloro-alpha-phenylbenzyl)piperazine
• TIMTEC-BB SBB002998
• 1-(4-CHLOROBENZHYDRYL)PIPERAZINE
• 1-(4-CHLORODIPHENYLMETHYL)-PIPERAZINE
• 1-(p-chloro-alpha-phenylbenzyl)-piperazin
• Piperazine, 1-(alpha-(4-chlorophenyl)benzyl)-
• AKOS BBS-00003606
• 1-(4-CHLOROBENZHYDRYL)PIPERAZINE, TECH.,
• 1-(alpha-Phenyl-4-chlorobenzyl)piperazine
• 1-[(4-CHLORO-PHENYL)-PHENYL-METHYL]-PIPERAZINE

1-(4-Chlorobenzhydryl)piperazine

CAS: 303-26-4

Formula: C₁₇H₁₉ClN₂

Purity: >98.0%(GC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 286.80

Ref: 3B-C1611

1-[(4-Chlorophenyl)phenylmethyl]piperazine

CAS: 303-26-4

Color and Shape: Neat

Ref: 61-FOR0380.01

MECLOZINE IMPURITY H CRS

CAS: 303-26-4

MECLOZINE IMPURITY H CRS

Formula: C₁₇H₁₉ClN₂

Color and Shape: May Be Present In Various Forms. Powder.

Molecular weight: 286.7992

Ref: 41-Y0001311

CETIRIZINE IMPURITY A CRS

CAS: 303-26-4

CETIRIZINE IMPURITY A CRS

Formula: C₁₇H₁₉ClN₂

Molecular weight: 286.7992

Ref: 41-C0980651

Hydroxyzine Related Compound A (1-[(4-Chlorophenyl)phenylmethyl]piperazine)

CAS: 303-26-4

Compounds containing a pyrimidine ring, whether or not hydrogenated, or piperazine ring in the structure, nesoi

Formula: C₁₇H₁₉ClN₂

Color and Shape: Powder

Molecular weight: 286.12368

Ref: 45-1333058

Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-

CAS: 303-26-4

Formula: C₁₇H₁₉ClN₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 286.7992

Ref: IN-DA002ZJZ

Norchlorcyclizine, 10mM (in DMSO)

CAS: 303-26-4

Norchlorcyclizine, 10mM (in DMSO)

Purity: ≥95%

Molecular weight: 286.8g/mol

Ref: 54-BUP19283

Cetirizine EP Impurity A (Levocetirizine EP Impurity I, Meclozine EP Impurity H, Hydroxyzine EP Impurity A, Hydroxyzine USP Related Compound A)

CAS: 303-26-4

Formula: C₁₇H₁₉ClN₂

Color and Shape: Off-White Solid

Molecular weight: 286.80

Ref: 4Z-C-208

(RS)-1-[(4-Chlorophenyl)phenylmethyl]piperazine

Controlled Product

CAS: 303-26-4

Formula: C₁₇H₁₉ClN₂

Color and Shape: Neat

Molecular weight: 286.80

Ref: 86-MM0380.01

1-(4-Chlorobenzhydryl)piperazine

CAS: 303-26-4

1-(4-Chlorobenzhydryl)piperazine

Purity: 98%

Molecular weight: 286.80g/mol

Ref: 54-OR4570

Norchlorcyclizine

CAS: 303-26-4

Norchlorcyclizine (C-10) is a partially selective NPR-B inhibitor. It also is an inhibitor of human tyrosyl-DNA phosphodiesterase 1.

Formula: C₁₇H₁₉ClN₂

Purity: 97.27%

Color and Shape: White Solid

Molecular weight: 286.8

Ref: TM-T20499

Buclizine Impurity 2

CAS: 303-26-4

Formula: C₁₇H₁₉ClN₂

Molecular weight: 286.80

Ref: ST-EA-CP-B30002

Cetirizine EP Impurity A

CAS: 303-26-4

Formula: C₁₇H₁₉ClN₂

Molecular weight: 286.79

Ref: ST-EA-CP-C14001

Levocetirizine EP Impurity I

CAS: 303-26-4

Formula: C₁₇H₁₉ClN₂

Molecular weight: 286.8

Ref: ST-EA-CP-L15001

1-[(4-Chlorophenyl)phenylmethyl]piperazine

Controlled Product

CAS: 303-26-4

Impurity Hydroxyzine EP Impurity A; Cetirizine Impurity A; Cetirizine USP A
Applications A metabolite of Cetirizine (C281100) and Hydroxyzine. Citirizine impurity A. Hydroxyzine EP Impurity A. Cetirizine Impurity A. Cetirizine USP A.
References Lewis, T., et al.: Bioorg. Med. Chem. Lett., 14, 2265 (2004),

Formula: C₁₇H₁₉ClN₂

Color and Shape: Neat

Molecular weight: 286.8

Ref: TR-C379575

1-[(4-Chlorophenyl)(phenyl)methyl]piperazine

CAS: 303-26-4

Formula: C₁₇H₁₉ClN₂

Purity: 90.0%

Color and Shape: Solid

Molecular weight: 286.8

Ref: 10-F068945

1-[(4-Chlorophenyl)phenylmethyl]piperazine

Controlled Product

CAS: 303-26-4

1-[(4-Chlorophenyl)phenylmethyl]piperazine is an analytical reagent that is used in the determination of meclozine, a drug used for the treatment of nausea and vomiting. 1-[(4-Chlorophenyl)phenylmethyl]piperazine is a nucleophile, which means that it can donate electrons to other molecules. It can be used as a catalyst to increase the rate of chemical reactions. 1-[(4-Chlorophenyl)phenylmethyl]piperazine may also be used in wastewater treatment because it has been shown to have phospholipidosis inhibiting properties. The levorotatory form (1R-enantiomer) of this compound has been shown to inhibit protein synthesis in vitro and is an amine oxidase inhibitor that binds to proteins with nitrogen atoms. This nucleophilic compound may also be converted into an n-oxide or dinucleotide phosphate by hydrochloric acid and

Formula: C₁₇H₁₉ClN₂

Purity: Min. 95%

Molecular weight: 286.8 g/mol

Ref: 3D-FC20350