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CAS 303-49-1

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Clomipramine

Description:
Clomipramine is a tricyclic antidepressant primarily used in the treatment of obsessive-compulsive disorder (OCD) and depression. It functions by inhibiting the reuptake of neurotransmitters, particularly serotonin and norepinephrine, thereby increasing their levels in the synaptic cleft and enhancing mood and emotional stability. Clomipramine is characterized by its complex chemical structure, which includes a dibenzazepine core. It is typically administered in oral form and is known for its sedative properties, which can be beneficial for patients with anxiety-related symptoms. Common side effects may include dry mouth, drowsiness, weight gain, and potential cardiovascular effects, necessitating careful monitoring. The drug's pharmacokinetics involve extensive metabolism in the liver, with a relatively long half-life, allowing for once-daily dosing in many cases. Due to its side effect profile and potential for overdose, clomipramine is generally prescribed with caution, particularly in individuals with a history of cardiovascular issues or those taking other medications that may interact adversely.
Formula:C19H23ClN2
InChI:InChI=1S/C19H23ClN2/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)22/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3
InChI key:InChIKey=GDLIGKIOYRNHDA-UHFFFAOYSA-N
SMILES:C(CCN(C)C)N1C=2C(CCC=3C1=CC=CC3)=CC=C(Cl)C2
Synonyms:
  • 10,11-dihydro-3-chloro-5-(3-(dimethylamino)propyl)-5H-dibenz(b,f)azepine
  • 206-144-2
  • 3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine
  • 3-Chloro-10,11-dihydro-5-(3-dimethylaminopropyl)-5H-dibenz[b,f]azepine
  • 3-Chloro-5-[3'-(dimethylamino) propyl]-10, 11-dihydro-5H-dibenzo[b,f]azepine
  • 3-Chloro-5-[3-(dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine
  • 3-chloro-10,11-dihydro-N,N-dimethyl-5H-Dibenz(b,f)azepine-5-propanamine
  • 5-(g-Dimethylaminopropyl)-3-chloroiminodibenzyl
  • 5H-Dibenz(b,f)azepine-5-propanamine, 3-chloro-10,11-dihydro-N,N-dimethyl-
  • 5H-Dibenz[b,f]azepine, 3-chloro-5-[3-(dimethylamino)propyl]-10,11-dihydro-
  • See more synonyms
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Found 4 products.