CAS 303-70-8

2-Hydroxyimipramine

Description:

2-Hydroxyimipramine is a chemical compound that belongs to the class of tricyclic antidepressants. It is characterized by its structure, which includes a hydroxyl group (-OH) attached to the imipramine framework, enhancing its pharmacological properties. This compound is primarily known for its role in the treatment of depression and other mood disorders, functioning by inhibiting the reuptake of neurotransmitters such as norepinephrine and serotonin in the brain. The presence of the hydroxyl group may influence its solubility and bioavailability compared to its parent compound, imipramine. 2-Hydroxyimipramine exhibits a range of pharmacological effects, including sedative and anxiolytic properties, and may also have implications in the treatment of chronic pain and anxiety disorders. Safety and efficacy profiles are essential for its therapeutic use, and like other tricyclic antidepressants, it may have side effects that require careful monitoring. Overall, 2-Hydroxyimipramine represents a significant compound in psychopharmacology, contributing to the understanding and management of mental health conditions.

Formula: C₁₉H₂₄N₂O

InChI: InChI=1S/C19H24N2O/c1-20(2)12-5-13-21-18-7-4-3-6-15(18)8-9-16-14-17(22)10-11-19(16)21/h3-4,6-7,10-11,14,22H,5,8-9,12-13H2,1-2H3

InChI key: InChIKey=ROTCPJFWLNDKHU-UHFFFAOYSA-N

SMILES: C(CCN(C)C)N1C=2C(CCC=3C1=CC=CC3)=CC(O)=CC2

Synonyms:

• 5H-Dibenz[b,f]azepin-2-ol, 5-[3-(dimethylamino)propyl]-10,11-dihydro-
• 5-[3-(Dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepin-2-ol
• G 33679
• 2-Hydroxyimipramine

2-Hydroxyimipramine

CAS: 303-70-8

Formula: C₁₉H₂₄N₂O

Color and Shape: Solid

Molecular weight: 296.4067

Ref: IN-DA002ZKH

2-Hydroxy Imipramine

CAS: 303-70-8

Formula: C₁₉H₂₄N₂O

Molecular weight: 296.41

Ref: 4Z-I-0113

2-Hydroxy Imipramine

Controlled Product

CAS: 303-70-8

Applications A metabolite of Imipramine.
References De Jongh, G.D., et al.: Drug Metab. Dispos., 2, 48 (1981), Suckow, R.F., et al.: J. Pharm. Sci., 73, 1745 (1984), Fraser, A.D., et al.: J. Anal. Toxicol., 11,168 (1987),

Formula: C₁₉H₂₄N₂O

Color and Shape: Yellowish Solid

Molecular weight: 296.41

Ref: TR-H943400

2-Hydroxy imipramine

CAS: 303-70-8

2-Hydroxy imipramine is a metabolite of imipramine, which is an antidepressant drug that belongs to the tricyclic antidepressant class. It is formed through enzyme hydrolysis by liver microsomes and monoclonal antibodies. 2-Hydroxy imipramine has been shown to have an affinity for the norepinephrine transporter in rat heart cells and human liver cells. The metabolism of 2-hydroxy imipramine can be inhibited by drugs such as chlorpromazine and fluoxetine, which induce hepatic enzymes responsible for the metabolic transformation of this drug. 2-Hydroxy imipramine may also have anti-inflammatory effects on cardiac tissue due to its ability to inhibit the activity of cytochrome P450, which are enzymes that metabolize many drugs in humans.

Formula: C₁₉H₂₄N₂O

Purity: (%) Min. 95%

Color and Shape: Brown Powder

Molecular weight: 296.41 g/mol

Ref: 3D-FH24021