CAS 3031-94-5

AICA Ribotide

Description:

AICA ribotide, also known as 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), is a nucleotide intermediate in the purine biosynthesis pathway. It is characterized by its structure, which includes a ribose sugar, an imidazole ring, and a carboxamide group. AICA ribotide plays a crucial role in cellular metabolism, particularly in the synthesis of adenine and guanine nucleotides. It is involved in the regulation of AMP-activated protein kinase (AMPK), which is important for energy homeostasis and metabolic processes. AICA ribotide is often studied for its potential therapeutic applications, including its effects on exercise performance and metabolic disorders. The compound is soluble in water and exhibits stability under physiological conditions, making it a valuable molecule in biochemical research. Its CAS number, 3031-94-5, is used for identification in chemical databases and regulatory contexts. Overall, AICA ribotide is significant in both fundamental biochemistry and potential clinical applications.

Formula: C₉H₁₅N₄O₈P

InChI: InChI=1S/C9H15N4O8P/c10-7-4(8(11)16)12-2-13(7)9-6(15)5(14)3(21-9)1-20-22(17,18)19/h2-3,5-6,9,14-15H,1,10H2,(H2,11,16)(H2,17,18,19)/t3-,5-,6-,9-/m1/s1

InChI key: InChIKey=NOTGFIUVDGNKRI-UUOKFMHZSA-N

SMILES: NC=1N(C=NC1C(N)=O)[C@@H]2O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]2O

Synonyms:

• AICAR
• Imidazole-4-carboxamide, 5-amino-1-β-D-ribofuranosyl-, 5′-(dihydrogen phosphate)
• Imidazole-4-carboxamide, 5-amino-1-β-D-ribofuranosyl-, 5′-phosphate
• 5-Amino-1-(5-O-phosphono-β-D-ribofuranosyl)-1H-imidazole-4-carboxamide
• 1H-Imidazole-4-carboxamide, 5-amino-1-(5-O-phosphono-β-D-ribofuranosyl)-

5'-Aminoimidazole-4-carboxamide-1-β-d-ribofuranosyl 5'-monophosphate

CAS: 3031-94-5

Formula: C₉H₁₅N₄O₈P

Purity: 95%

Color and Shape: Solid

Molecular weight: 338.2112

Ref: IN-DA00C232

5-Aminoimidazole-4-carboxamide-1-b-D-ribofuranose 5''-monophosphate

CAS: 3031-94-5

Ref: 7W-GN3957

5-Aminoimidazole-4-carboxamide-1-β-D-Ribofuranosyl 5’-Monophosphate

Controlled Product

CAS: 3031-94-5

Formula: C₉H₁₅N₄O₈P

Color and Shape: Neat

Molecular weight: 338.21

Ref: TR-A611705

5-Aminoimidazole-4-carboxamide-1-b-D-ribofuranose 5'-monophosphate

Controlled Product

CAS: 3031-94-5

5-Aminoimidazole-4-carboxamide-1-b-D-ribofuranose 5'-monophosphate (AICAR) is an analogue of AMP that activates the AMPK pathway. It is a potent activator that increases the activity of this enzyme, which regulates cellular energy metabolism. AICAR has been shown to induce significant cytotoxicity in k562 cells and to increase the levels of ATP in these cells. This compound has also been shown to have potential use in metabolic disorders, such as type 2 diabetes, by increasing uptake and kinetic of glucose. AICAR has also been shown to activate the AMPK pathway in prostate cancer cells and increase cellular physiology.

Formula: C₉H₁₅N₄O₈P

Purity: Min. 95 Area-%

Color and Shape: White Powder

Molecular weight: 338.21 g/mol

Ref: 3D-NA07204

AICAR monophosphate

CAS: 3031-94-5

AICAR monophosphate (Aica ribonucleotide) is a purine precursor with antineoplastic activity and can be used in studies about type 2 diabetes.

Formula: C₉H₁₅N₄O₈P

Purity: 99.8%

Color and Shape: Solid

Molecular weight: 338.21

Ref: TM-T21195