PROTAC α-synuclein degrader 6, identified by its CAS number 3032208-24-2, is a small molecule designed for targeted protein degradation, specifically aimed at α-synuclein, a protein implicated in neurodegenerative diseases such as Parkinson's disease. This compound belongs to a class of molecules known as PROTACs (Proteolysis Targeting Chimeras), which function by harnessing the ubiquitin-proteasome system to selectively degrade target proteins. The structure of PROTAC α-synuclein degrader 6 typically consists of a ligand that binds to the target protein (α-synuclein) and another ligand that recruits an E3 ubiquitin ligase, facilitating the ubiquitination and subsequent degradation of the target protein. This mechanism allows for a more precise modulation of protein levels compared to traditional inhibitors, potentially leading to improved therapeutic outcomes. The development of such degraders represents a promising strategy in drug discovery, particularly for diseases characterized by protein aggregation and misfolding. Further research is ongoing to evaluate its efficacy and safety in biological systems.

PROTAC α-synuclein degrader 6

3032208-24-2: PROTAC α-synuclein degrader 6, identified by its CAS number 3032208-24-2, is a small molecule designed for targeted protein degradation, specifically aimed at α-synuclein, a protein implicated in neurodegenerative diseases such as Parkinson's disease. This compound belongs to a class of molecules known as PROTACs (Proteolysis Targeting Chimeras), which function by harnessing the ubiquitin-proteasome system to selectively degrade target proteins. The structure of PROTAC α-synuclein degrader 6 typically consists of a ligand that binds to the target protein (α-synuclein) and another ligand that recruits an E3 ubiquitin ligase, facilitating the ubiquitination and subsequent degradation of the target protein. This mechanism allows for a more precise modulation of protein levels compared to traditional inhibitors, potentially leading to improved therapeutic outcomes. The development of such degraders represents a promising strategy in drug discovery, particularly for diseases characterized by protein aggregation and misfolding. Further research is ongoing to evaluate its efficacy and safety in biological systems.

<p>PROTACα-synuclein degrader 6 (compound T3) is a PROTAC degrader of α-synuclein and tau, with an EC50 of 1.57 μM and 4.09 μM, respectively. This compound plays a significant role in neurodegenerative disease (ND) research.</p>

CAS 3032208-24-2

PROTAC α-synuclein degrader 6

PROTAC α-synuclein degrader 6

Ref: TM-T209298