CAS 3032576-92-1

INNO-220

Formula: C₂₃H₂₀N₄O₃

Synonyms:

• INNO-220
• 2,6-Piperidinedione, 3-[1,3-dihydro-5-(1-methyl-5-phenyl-1H-pyrazol-4-yl)-1-oxo-2H-isoindol-2-yl]-

INNO-220

CAS: 3032576-92-1

INNO-220 is an orally active, CRBN-dependent molecular glue degrader that targets CK1α. By degrading CK1α, INNO-220 induces cell cycle arrest at the G0/G1 phase and triggers apoptosis (Apoptosis). It disrupts the assembly and function of the CARD11/BCL10/MALT1 complex, inhibiting the NF-κB signaling pathway in T cells and lymphoma cells with activating mutations in CARD11. INNO-220 offers a novel direction for lymphoma research.

Formula: C₂₃H₂₀N₄O₃

Color and Shape: Solid

Molecular weight: 400.43

Ref: TM-T211026