ASCT2-IN-1, identified by its CAS number 3032651-18-3, is a chemical compound that serves as an inhibitor of the alanine-serine-cysteine transporter 2 (ASCT2). This transporter is crucial for the uptake of amino acids, particularly in cancer cells, making ASCT2-IN-1 a potential candidate for therapeutic applications in oncology. The compound is characterized by its ability to selectively inhibit ASCT2, thereby disrupting amino acid transport and potentially leading to reduced tumor growth. Its molecular structure typically includes functional groups that enhance its binding affinity to the transporter. ASCT2-IN-1 is often studied in the context of drug development, particularly for its efficacy and safety profiles in preclinical models. As with many small molecule inhibitors, understanding its pharmacokinetics, bioavailability, and metabolic pathways is essential for evaluating its therapeutic potential. Further research is necessary to elucidate its mechanism of action and to explore its effectiveness in combination with other cancer therapies.

ASCT2-IN-1

3032651-18-3: ASCT2-IN-1, identified by its CAS number 3032651-18-3, is a chemical compound that serves as an inhibitor of the alanine-serine-cysteine transporter 2 (ASCT2). This transporter is crucial for the uptake of amino acids, particularly in cancer cells, making ASCT2-IN-1 a potential candidate for therapeutic applications in oncology. The compound is characterized by its ability to selectively inhibit ASCT2, thereby disrupting amino acid transport and potentially leading to reduced tumor growth. Its molecular structure typically includes functional groups that enhance its binding affinity to the transporter. ASCT2-IN-1 is often studied in the context of drug development, particularly for its efficacy and safety profiles in preclinical models. As with many small molecule inhibitors, understanding its pharmacokinetics, bioavailability, and metabolic pathways is essential for evaluating its therapeutic potential. Further research is necessary to elucidate its mechanism of action and to explore its effectiveness in combination with other cancer therapies.

<p>ASCT2-IN-1 (compound 20k) is an inhibitor of ASCT2, demonstrating IC50 values of 5.6 μM in A549 cells and 3.5 μM in HEK293 cells. It induces apoptosis and inhibits tumor growth.</p>

CAS 3032651-18-3

ASCT2-IN-1

ASCT2-IN-1

Ref: TM-T209188