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CAS 3033690-83-1

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  • KRAS inhibitor-27
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    KRAS inhibitor-27

    CAS:
    <p>KRAS inhibitor-27 (Compound 15h) is a KRAS inhibitor that effectively targets KRAS G12D/G12V mutated cells (AsPC-1 and SW620) and wild-type KRAS cells (HT-29), with IC50 values of 378 nM, 0.6 nM, and 3230 nM, respectively. It reduces ERK phosphorylation, with IC50 values of 0.6 nM and 1 nM in AsPC-1 and SW620 cells, respectively, and decreases DUSP4 expression, thereby inhibiting the MAPK signaling pathway.</p>
    Formula:C31H28ClF3N6O3S
    Color and Shape:Solid
    Molecular weight:657.106

    Ref: TM-T205081