PRMT5-IN-37, identified by its CAS number 3034033-98-9, is a small molecule inhibitor specifically targeting protein arginine methyltransferase 5 (PRMT5). This enzyme plays a crucial role in various cellular processes, including gene expression, RNA processing, and cell signaling, by catalyzing the methylation of arginine residues on target proteins. The inhibition of PRMT5 has garnered interest in cancer research, as its dysregulation is often associated with tumorigenesis and cancer progression. PRMT5-IN-37 is characterized by its ability to selectively bind to the active site of PRMT5, thereby blocking its enzymatic activity. This compound is typically evaluated in preclinical studies for its efficacy and safety profile, with potential applications in therapeutic strategies for cancers and other diseases linked to PRMT5 activity. Its chemical structure and properties, including solubility and stability, are essential for optimizing its pharmacokinetic and pharmacodynamic profiles in drug development.

PRMT5-IN-37

3034033-98-9: PRMT5-IN-37, identified by its CAS number 3034033-98-9, is a small molecule inhibitor specifically targeting protein arginine methyltransferase 5 (PRMT5). This enzyme plays a crucial role in various cellular processes, including gene expression, RNA processing, and cell signaling, by catalyzing the methylation of arginine residues on target proteins. The inhibition of PRMT5 has garnered interest in cancer research, as its dysregulation is often associated with tumorigenesis and cancer progression. PRMT5-IN-37 is characterized by its ability to selectively bind to the active site of PRMT5, thereby blocking its enzymatic activity. This compound is typically evaluated in preclinical studies for its efficacy and safety profile, with potential applications in therapeutic strategies for cancers and other diseases linked to PRMT5 activity. Its chemical structure and properties, including solubility and stability, are essential for optimizing its pharmacokinetic and pharmacodynamic profiles in drug development.

<p>PRMT5-IN-37 (compound 29), an orally active inhibitor of PRMT5, is utilized for cancer research.</p>

CAS 3034033-98-9

PRMT5-IN-37

PRMT5-IN-37

Ref: TM-T88137