PROTAC EGFR degrader 11 is a small molecule designed for targeted protein degradation, specifically targeting the epidermal growth factor receptor (EGFR). This compound belongs to a class of molecules known as PROTACs (proteolysis-targeting chimeras), which harness the cell's ubiquitin-proteasome system to selectively degrade specific proteins. The structure of PROTAC EGFR degrader 11 typically includes a ligand that binds to EGFR, a linker, and a ligand that recruits an E3 ubiquitin ligase, facilitating the ubiquitination and subsequent degradation of the target protein. This approach allows for the modulation of protein levels in a more controlled manner compared to traditional inhibitors, potentially leading to reduced side effects and improved therapeutic outcomes. The compound is of particular interest in cancer research, where aberrant EGFR signaling is often implicated. Its efficacy and safety profile are subjects of ongoing research, as scientists explore its potential applications in treating various malignancies associated with EGFR dysregulation.

PROTAC EGFR degrader 11

3034244-71-5: PROTAC EGFR degrader 11 is a small molecule designed for targeted protein degradation, specifically targeting the epidermal growth factor receptor (EGFR). This compound belongs to a class of molecules known as PROTACs (proteolysis-targeting chimeras), which harness the cell's ubiquitin-proteasome system to selectively degrade specific proteins. The structure of PROTAC EGFR degrader 11 typically includes a ligand that binds to EGFR, a linker, and a ligand that recruits an E3 ubiquitin ligase, facilitating the ubiquitination and subsequent degradation of the target protein. This approach allows for the modulation of protein levels in a more controlled manner compared to traditional inhibitors, potentially leading to reduced side effects and improved therapeutic outcomes. The compound is of particular interest in cancer research, where aberrant EGFR signaling is often implicated. Its efficacy and safety profile are subjects of ongoing research, as scientists explore its potential applications in treating various malignancies associated with EGFR dysregulation.

<p>PROTAC EGFR degrader 11 (Compound B71) is a PROTAC degrader targeting the epidermal growth factor receptor (EGFR), with a DC50 of less than 100 nM. It binds to CRBN-DDB1 with a Ki of 36 nM. This compound effectively degrades EGFR, focal adhesion kinase (FAK), and RSK1, and inhibits the proliferation of BaF3 wild-type and EGFR mutant cells, exhibiting an IC50 of less than 100 nM.</p>

CAS 3034244-71-5

PROTAC EGFR degrader 11

PROTAC EGFR degrader 11

Ref: TM-T88077