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CAS 3034605-72-3

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  • HVH-2930
    Targetmol
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    HVH-2930

    CAS:
    <p>HVH-2930 is an inhibitor of Heat Shock Protein 90 (HSP90). It suppresses the cell viability of BT474 (Trastuzumab sensitive) and JIMT-1 (Trastuzumab resistant) by downregulating HSP90 client proteins such as HER2, p-HER2, AKT, p-AKT, cyclin D1, and survivin, with IC50 values of 6.86 μM and 4.42 μM, respectively. Additionally, HVH-2930 demonstrates antitumor efficacy in a mouse model and exhibits favorable pharmacokinetic properties in vivo.</p>
    Formula:C29H36N4O3
    Color and Shape:Solid
    Molecular weight:488.62

    Ref: TM-T88646