TLR8 agonist 7, identified by its CAS number 3034750-26-7, is a synthetic compound that acts as an agonist for Toll-like receptor 8 (TLR8), a member of the Toll-like receptor family involved in the immune response. This compound is characterized by its ability to stimulate TLR8, leading to the activation of various signaling pathways that enhance the immune response, particularly in the context of viral infections and cancer. TLR8 agonists are of significant interest in immunotherapy and vaccine development due to their potential to modulate immune responses. The chemical structure of TLR8 agonist 7 typically includes specific functional groups that facilitate its interaction with the receptor, promoting the release of pro-inflammatory cytokines. Additionally, its pharmacokinetic properties, such as solubility and stability, are crucial for its efficacy in biological systems. Research into TLR8 agonists like this compound continues to explore their therapeutic applications and mechanisms of action in various disease contexts.

TLR8 agonist 7

3034750-26-7: TLR8 agonist 7, identified by its CAS number 3034750-26-7, is a synthetic compound that acts as an agonist for Toll-like receptor 8 (TLR8), a member of the Toll-like receptor family involved in the immune response. This compound is characterized by its ability to stimulate TLR8, leading to the activation of various signaling pathways that enhance the immune response, particularly in the context of viral infections and cancer. TLR8 agonists are of significant interest in immunotherapy and vaccine development due to their potential to modulate immune responses. The chemical structure of TLR8 agonist 7 typically includes specific functional groups that facilitate its interaction with the receptor, promoting the release of pro-inflammatory cytokines. Additionally, its pharmacokinetic properties, such as solubility and stability, are crucial for its efficacy in biological systems. Research into TLR8 agonists like this compound continues to explore their therapeutic applications and mechanisms of action in various disease contexts.

<p>TLR8 agonist7 is an agonist of Toll-like receptor 8 (TLR8) with an EC50 of less than 250 nM. It remains stable in human and mouse plasma and induces the secretion of the cytokine TNFα with an EC50 of less than 1 μM. In the MC38-HER2 xenograft mouse model, TLR8 agonist7 demonstrates antitumor activity, achieving a tumor growth inhibition (TGI) rate of 98%.</p>

CAS 3034750-26-7

TLR8 agonist 7

TLR8 agonist 7

Ref: TM-T88108