TLR8 agonist 8, identified by its CAS number 3034750-58-5, is a synthetic compound that acts as an agonist for Toll-like receptor 8 (TLR8), a member of the Toll-like receptor family involved in the immune response. This compound is characterized by its ability to stimulate the innate immune system, promoting the activation of immune cells such as macrophages and dendritic cells. TLR8 agonists are of significant interest in immunotherapy and vaccine development due to their potential to enhance antiviral and antitumor responses. The chemical structure of TLR8 agonist 8 typically includes specific functional groups that facilitate its interaction with the receptor, leading to the activation of downstream signaling pathways. This activation results in the production of pro-inflammatory cytokines and chemokines, which play crucial roles in orchestrating the immune response. Additionally, the compound's pharmacokinetic properties, such as solubility and stability, are important for its efficacy in therapeutic applications. Overall, TLR8 agonist 8 represents a valuable tool in the field of immunology and therapeutic development.

TLR8 agonist 8

3034750-58-5: TLR8 agonist 8, identified by its CAS number 3034750-58-5, is a synthetic compound that acts as an agonist for Toll-like receptor 8 (TLR8), a member of the Toll-like receptor family involved in the immune response. This compound is characterized by its ability to stimulate the innate immune system, promoting the activation of immune cells such as macrophages and dendritic cells. TLR8 agonists are of significant interest in immunotherapy and vaccine development due to their potential to enhance antiviral and antitumor responses. The chemical structure of TLR8 agonist 8 typically includes specific functional groups that facilitate its interaction with the receptor, leading to the activation of downstream signaling pathways. This activation results in the production of pro-inflammatory cytokines and chemokines, which play crucial roles in orchestrating the immune response. Additionally, the compound's pharmacokinetic properties, such as solubility and stability, are important for its efficacy in therapeutic applications. Overall, TLR8 agonist 8 represents a valuable tool in the field of immunology and therapeutic development.

<p>TLR8 agonist8 (Compound II-72) is an agonist of Toll-like receptor 8 (TLR8) with an EC50 of 0.25-1 μM. It demonstrates stability in both human and mouse plasma and induces the secretion of the cytokine TNFα with an EC50 of less than 1 μM. In the MC38-HER2 xenograft mouse model, TLR8 agonist8 exhibits antitumor activity, achieving a tumor growth inhibition (TGI) rate of 89%.</p>

CAS 3034750-58-5

TLR8 agonist 8

TLR8 agonist 8

Ref: TM-T88252