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CAS 3035018-34-6

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  • Brefeldin A 4-O-nicotinate
    Targetmol
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    Brefeldin A 4-O-nicotinate

    CAS:
    <p>Brefeldin A 4-O-nicotinate (CHNQD-01228) is a dual inhibitor of Arf1 and BMX proteins with an IC50 value of 0.22 μM for T24 cell proliferation. It also suppresses T24 cell migration and colony formation in a dose-dependent manner, induces G1 phase arrest, and triggers apoptosis. By targeting BMX proteins, it inhibits the AKT/p-AKT and STAT3/p-STAT3 signaling pathways, while also inhibiting Arf1 proteins to eliminate bladder cancer stem cells and activate antitumor immunity, thus exhibiting anticancer activity. Brefeldin A 4-O-nicotinate is applicable in research related to bladder cancer.</p>
    Formula:C22H27NO5
    Color and Shape:Solid
    Molecular weight:385.453

    Ref: TM-T206652