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CAS 3035311-43-1

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  • ER degrader 10
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    ER degrader 10

    CAS:
    <p>ER degrader 10 (Compound 51) is an orally active estrogen receptor (ER) selective degrader and antagonist, with a DC50 of 0.43 nM and an IC50 of 0.56 nM. It inhibits the proliferation of ER-positive cells, with an IC50 ranging from 0 to 15 nM. ER degrader 10 exhibits weak inhibitory activity on the hERG channel, with an IC50 greater than 40 μM. It has blood-brain barrier permeability, with a brain/plasma ratio (Kp) of 3.05. In mouse models, ER degrader 10 demonstrates antitumor activity.</p>
    Formula:C28H29F2NO3S
    Color and Shape:Solid
    Molecular weight:497.597

    Ref: TM-T204775