CAS 3035639-05-2

Cyclopropanesulfonamide, N-[2-[[5-bromo-2-[[4-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-

Description:

Cyclopropanesulfonamide, N-[2-[[5-bromo-2-[[4-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]- is a complex organic compound characterized by its unique structural features, including a cyclopropane ring and a sulfonamide functional group. The presence of a bromine atom and a hexahydro-4-methyl-1H-1,4-diazepin moiety contributes to its potential biological activity, possibly influencing its pharmacological properties. This compound may exhibit properties typical of sulfonamides, such as antibacterial or antitumor activity, depending on its specific interactions with biological targets. The intricate arrangement of aromatic and heterocyclic components suggests potential for diverse chemical reactivity and interactions. Additionally, the compound's solubility, stability, and reactivity can be influenced by the substituents on the aromatic rings and the overall molecular geometry. As with many synthetic organic compounds, understanding its characteristics requires consideration of its synthesis, potential applications, and safety profile in laboratory and therapeutic contexts.

Formula: C₂₅H₃₀BrN₇O₂S

Synonyms:

• Cyclopropanesulfonamide, N-[2-[[5-bromo-2-[[4-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-

EGFR-IN-117

CAS: 3035639-05-2

EGFR-IN-117 (Compound 8h) exhibits inhibitory activity against EGFR mutations, specifically targeting the tumor environment and inducing apoptosis in cancer cells. This compound effectively inhibits the proliferation of H1975, PC-9, and mutant EGFR cells including BaF3-EGFRL858R/T790M/C797S and BaF3–C797S/Del19/T790M, with IC50 values of 13 nM, 19 nM, 1.2 nM, and 1.3 nM respectively. Additionally, EGFR-IN-117 demonstrates anti-tumor activity in mouse models.

Formula: C₂₅H₃₀BrN₇O₂S

Color and Shape: Solid

Molecular weight: 572.52

Ref: TM-T88785