JAK2-IN-10, identified by its CAS number 3035735-18-0, is a small molecule inhibitor specifically targeting the Janus kinase 2 (JAK2) enzyme, which plays a crucial role in various signaling pathways, particularly those related to hematopoiesis and immune response. This compound is of interest in the field of medicinal chemistry and pharmacology due to its potential therapeutic applications in treating diseases associated with JAK2 dysregulation, such as certain types of cancers and myeloproliferative disorders. Characteristically, JAK2-IN-10 exhibits a specific binding affinity to the JAK2 enzyme, inhibiting its activity and thereby modulating downstream signaling pathways. The compound's efficacy and safety profile are typically evaluated through preclinical and clinical studies, focusing on its pharmacokinetics, bioavailability, and potential side effects. As research progresses, JAK2-IN-10 may contribute to the development of targeted therapies aimed at improving patient outcomes in conditions linked to JAK2 mutations or overactivity.

JAK2-IN-10

3035735-18-0: JAK2-IN-10, identified by its CAS number 3035735-18-0, is a small molecule inhibitor specifically targeting the Janus kinase 2 (JAK2) enzyme, which plays a crucial role in various signaling pathways, particularly those related to hematopoiesis and immune response. This compound is of interest in the field of medicinal chemistry and pharmacology due to its potential therapeutic applications in treating diseases associated with JAK2 dysregulation, such as certain types of cancers and myeloproliferative disorders. Characteristically, JAK2-IN-10 exhibits a specific binding affinity to the JAK2 enzyme, inhibiting its activity and thereby modulating downstream signaling pathways. The compound's efficacy and safety profile are typically evaluated through preclinical and clinical studies, focusing on its pharmacokinetics, bioavailability, and potential side effects. As research progresses, JAK2-IN-10 may contribute to the development of targeted therapies aimed at improving patient outcomes in conditions linked to JAK2 mutations or overactivity.

<p>JAK2-IN-10 (compound 5) is a potent inhibitor of JAK2v617f, with an IC50 value of ≤10 nM.</p>

CAS 3035735-18-0

JAK2-IN-10

JAK2-IN-10

Ref: TM-T88297