PROTAC SOS1 degrader-7 is a small molecule designed as a targeted protein degradation agent, specifically targeting the SOS1 protein, which plays a crucial role in RAS signaling pathways. This compound belongs to the class of PROTACs (Proteolysis Targeting Chimeras), which utilize the cellular ubiquitin-proteasome system to selectively degrade specific proteins. The structure of PROTAC SOS1 degrader-7 typically consists of a ligand that binds to the target protein (SOS1) and another ligand that recruits an E3 ubiquitin ligase, facilitating the ubiquitination and subsequent degradation of the target protein. This mechanism allows for the modulation of protein levels in a highly selective manner, offering potential therapeutic applications in cancer treatment, particularly in tumors driven by RAS mutations. The compound's efficacy, selectivity, and pharmacokinetic properties are critical for its development as a therapeutic agent, and ongoing research aims to optimize these characteristics for clinical use.

PROTAC SOS1 degrader-7

3036155-26-4: PROTAC SOS1 degrader-7 is a small molecule designed as a targeted protein degradation agent, specifically targeting the SOS1 protein, which plays a crucial role in RAS signaling pathways. This compound belongs to the class of PROTACs (Proteolysis Targeting Chimeras), which utilize the cellular ubiquitin-proteasome system to selectively degrade specific proteins. The structure of PROTAC SOS1 degrader-7 typically consists of a ligand that binds to the target protein (SOS1) and another ligand that recruits an E3 ubiquitin ligase, facilitating the ubiquitination and subsequent degradation of the target protein. This mechanism allows for the modulation of protein levels in a highly selective manner, offering potential therapeutic applications in cancer treatment, particularly in tumors driven by RAS mutations. The compound's efficacy, selectivity, and pharmacokinetic properties are critical for its development as a therapeutic agent, and ongoing research aims to optimize these characteristics for clinical use.

<p>PROTACSOS1 degrader-7 (Example 15) is a SOS1 PROTAC degrader with specific antitumor activity.</p>

CAS 3036155-26-4

PROTAC SOS1 degrader-7

PROTAC SOS1 degrader-7

Ref: TM-T88242