CAS 3036581-87-7
:Propafenone Impurity 48 (N-Nitroso Propafenone)
Description:
Propafenone Impurity 48, also known as N-Nitroso Propafenone, is a chemical compound associated with the pharmaceutical agent propafenone, which is primarily used as an antiarrhythmic medication. This impurity is characterized by the presence of a nitroso functional group (-N=O) attached to the propafenone structure, which can influence its chemical reactivity and biological activity. The presence of the nitroso group may raise concerns regarding its stability and potential toxicity, as nitroso compounds are often associated with mutagenic and carcinogenic properties. In terms of physical characteristics, N-Nitroso Propafenone is typically a solid at room temperature, and its solubility may vary depending on the solvent used. Analytical methods such as high-performance liquid chromatography (HPLC) and mass spectrometry are commonly employed to detect and quantify this impurity in pharmaceutical formulations. Understanding the characteristics and implications of such impurities is crucial for ensuring the safety and efficacy of drug products.
Formula:C21H26N2O4
Synonyms:- N-nitrosopropene
- N-nitrosopropoxypropanone
- N-(2-hydroxy-3-(2-(3-phenylpropanoyl)phenoxy)propyl)-N-propylnitrous amide
- 1-Propanone, 1-[2-[2-hydroxy-3-(nitrosopropylamino)propoxy]phenyl]-3-phenyl-
- Propafenone Impurity 48 (N-Nitroso Propafenone)
- Propafenone Impurity 20
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