L1Au2, with the CAS number 3038386-42-1, is a chemical compound that features a unique combination of elements, primarily involving gold (Au) in its structure. This compound is characterized by its potential applications in various fields, including catalysis and materials science, due to the properties imparted by the gold atoms. The presence of ligands or other coordinating entities in its structure can influence its reactivity, stability, and solubility. Typically, compounds like L1Au2 may exhibit interesting electronic properties, making them suitable for use in electronic devices or as catalysts in chemical reactions. Additionally, the specific arrangement of atoms and the nature of the bonding can lead to distinctive physical properties, such as color and melting point. As with many gold-containing compounds, L1Au2 may also demonstrate unique interactions with light, which can be exploited in optical applications. Overall, the characteristics of L1Au2 highlight its significance in advanced materials and nanotechnology research.

L1Au2 is a dual inhibitor of EGFR and thioredoxin reductase (TrxR; IC50 = 0.99 µM).{72756|} It inhibits the phosphorylation of EGFR, Akt, and ERK in PC-9 lung cancer cells, which express EGFR containing the exon 19 deletion, when used at concentrations of 0.01 or 0.05 µM. L1Au2 inhibits the proliferation of PC-9 and gefitinib-resistant PC-9 cells (IC50s = 0.012 and 1.76 µM, respectively) and induces ferroptosis in gefitinib-resistant PC-9 cells. In vivo, L1Au2 (10 mg/kg) decreases tumor weight and intratumoral glutathione peroxidase 4 (Gpx4) levels in a gefitinib-resistant PC-9 mouse xenograft model.WARNING This product is not for human or veterinary use.

​​L1Au2

3038386-42-1: L1Au2, with the CAS number 3038386-42-1, is a chemical compound that features a unique combination of elements, primarily involving gold (Au) in its structure. This compound is characterized by its potential applications in various fields, including catalysis and materials science, due to the properties imparted by the gold atoms. The presence of ligands or other coordinating entities in its structure can influence its reactivity, stability, and solubility. Typically, compounds like L1Au2 may exhibit interesting electronic properties, making them suitable for use in electronic devices or as catalysts in chemical reactions. Additionally, the specific arrangement of atoms and the nature of the bonding can lead to distinctive physical properties, such as color and melting point. As with many gold-containing compounds, L1Au2 may also demonstrate unique interactions with light, which can be exploited in optical applications. Overall, the characteristics of L1Au2 highlight its significance in advanced materials and nanotechnology research.

<p>TrxR/EGFR-IN-1 (Compound L1Au2) is a TrxR/EGFR inhibitor with activity against both gefitinib-sensitive and -resistant lung cancer, effectively suppressing tumor proliferation and promoting apoptosis. It enhances GPX4 degradation through autophagosome-lysosome and proteasome pathways, leading to ferroptosis. Additionally, it induces endoplasmic reticulum stress and triggers immunogenic cell death, making it applicable for studies on gefitinib-resistant lung cancer.</p>

CAS 3038386-42-1

L1Au2

TrxR/EGFR-IN-1

Ref: TM-T205519

CAS 3038386-42-1

​​L1Au2

TrxR/EGFR-IN-1

Ref: TM-T205519

L1Au2