CAS 3038446-90-8

JB 300

Description:

As of my last update in October 2023, "JB 300" with the CAS number 3038446-90-8 is not widely recognized in the scientific literature or chemical databases, which may indicate that it is a proprietary compound or a substance with limited public information. Typically, substances with specific CAS numbers can be identified by their chemical structure, properties, and applications. Characteristics of a chemical substance generally include its molecular formula, physical state (solid, liquid, gas), melting and boiling points, solubility, reactivity, and potential uses in various fields such as pharmaceuticals, materials science, or industrial applications. If "JB 300" is a novel compound or under research, detailed information may be available in specialized databases or publications. For accurate and comprehensive data, consulting scientific literature or databases specific to chemical substances would be necessary.

Formula: C₄₃H₄₅ClFN₇O₁₀S

Synonyms:

• Cyclohexanecarboxamide, 4-(3-chloro-2-fluorophenoxy)-N-[2-[2-[2-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]ethoxy]ethoxy]ethyl]-1-[[6-(2-thiazolylamino)-2-pyridinyl]methyl]-, trans-
• JB 300

JB300

CAS: 3038446-90-8

JB300 is a PROTAC-based compound that serves as a highly selective degrader of Aurora A, with a DC50 of 30 nM. It is utilized in cancer research. JB300 comprises the PROTAC target protein ligand MK-5108 [pink part], E3 ligase ligand Thalidomide-O-COOH [blue part], and PROTAC Linker Boc-NH-PEG2-C2-NH2 [black part]. The conjugate of the E3 ubiquitin ligase ligand and linker is Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc.

Formula: C₄₃H₄₅ClFN₇O₁₀S

Color and Shape: Solid

Molecular weight: 906.375

Ref: TM-T204223