CAS 30387-39-4

Colistimethate Sodium

Description:

Colistimethate sodium, also known as colistin methanesulfonate, is an antibiotic that belongs to the polymyxin class of antibiotics. It is primarily used to treat infections caused by multidrug-resistant Gram-negative bacteria, particularly Pseudomonas aeruginosa and Acinetobacter baumannii. The substance is a prodrug of colistin, which is the active form that exerts its antibacterial effects by disrupting the bacterial cell membrane. Colistimethate sodium is typically administered intravenously or via inhalation, especially in cases of severe infections. Its solubility in water allows for effective delivery in clinical settings. However, its use is often limited by potential nephrotoxicity and neurotoxicity, necessitating careful monitoring of renal function during treatment. The emergence of resistance to colistin has raised concerns, making it a last-resort option in antibiotic therapy. Overall, colistimethate sodium plays a critical role in combating resistant infections, but its use must be judicious to preserve its efficacy.

Formula: C₅₈H₁₀₅N₁₆Na₅O₂₈S₅

InChI: InChI=1/C58H110N16O28S5.5Na/c1-9-35(6)12-10-11-13-46(77)65-38(14-20-59-28-103(88,89)90)53(82)74-48(37(8)76)58(87)70-41(17-23-62-31-106(97,98)99)50(79)68-43-19-25-64-57(86)47(36(7)75)73-54(83)42(18-24-63-32-107(100,101)102)67-49(78)39(15-21-60-29-104(91,92)93)69-55(84)44(26-33(2)3)72-56(85)45(27-34(4)5)71-52(81)40(66-51(43)80)16-22-61-30-105(94,95)96;;;;;/h33-45,47-48,59-63,75-76H,9-32H2,1-8H3,(H,64,86)(H,65,77)(H,66,80)(H,67,78)(H,68,79)(H,69,84)(H,70,87)(H,71,81)(H,72,85)(H,73,83)(H,74,82)(H,88,89,90)(H,91,92,93)(H,94,95,96)(H,97,98,99)(H,100,101,102);;;;;/q;5*+1/p-5

SMILES: CCC(C)CCCCC(=NC(CCNCS(=O)(=O)O)C(=NC(C(C)O)C(=NC(CCNCS(=O)(=O)O)C(=NC1CCN=C(C(C(C)O)N=C(C(CCNCS(=O)(=O)O)N=C(C(CCNCS(=O)(=O)O)N=C(C(CC(C)C)N=C(C(CC(C)C)N=C(C(CCNCS(=O)(=O)O)N=C1O)O)O)O)O)O)O)O)O)O)O.[Na].[Na].[Na].[Na].[Na]

Synonyms:

• Colimicina
• Colimycin M
• Colimyscine
• Colistimethate
• Colistin sodium methanesulfonate
• Colistin sulfomethate
• Colistin sulfomethate sodium
• Colistinemethanesulfonate sodique
• Colistrimethate sodium
• Colomycin
• Coly-Mycin M
• Coly-Mycin M Parenteral
• Coly-mycin
• Coly-mycin injectable
• Colymycin M
• Pentasodium colistinmethanesulfonate
• Sodium colistimethate
• Sodium colistin methanesulfonate
• Sodium colistinemethanesulfonate
• W 1929
• Colistinmethanesulfonic acid, sodium salt

Colistimethate Sodium

CAS: 30387-39-4

Colistimethate Sodium

Purity: ≥98%

Molecular weight: 1545.82g/mol

Ref: 54-BUP10096

Polymyxin E1 (Methanesulfonic Sodium Unspecified)

CAS: 30387-39-4

Formula: C₅₃H₉₀N₁₆O₁₃·mHC₅₃H₉₀N₁₆O₁₃·nCH₂O₃S·Na

Molecular weight: 1545.82

Ref: 4Z-PP-321023

Colistimethate Sodium

CAS: 30387-39-4

Colistimethate Sodium treats serious Gram-negative infections in patients with few options.

Formula: C₅₇H₁₀₈N₁₆O₂₅S₄

Purity: ≥98%

Color and Shape: Solid

Molecular weight: 1545.82

Ref: TM-T3501