HuR degrader 2, identified by its CAS number 3040301-46-7, is a small molecule designed to selectively target and degrade the human antigen R (HuR) protein, which plays a significant role in post-transcriptional regulation of gene expression. This compound is part of a class of molecules known as proteolysis-targeting chimeras (PROTACs), which harness the cellular ubiquitin-proteasome system to promote the degradation of specific proteins. HuR is implicated in various cellular processes, including mRNA stability and translation, and is associated with several diseases, including cancer. The characteristics of HuR degrader 2 include its ability to bind to HuR and an E3 ubiquitin ligase, facilitating the ubiquitination and subsequent degradation of HuR. This mechanism of action allows for the modulation of gene expression profiles, making HuR degrader 2 a potential therapeutic agent in conditions where HuR is dysregulated. Its development reflects a growing interest in targeted protein degradation as a strategy for drug discovery and therapeutic intervention.

HuR degrader 2

3040301-46-7: HuR degrader 2, identified by its CAS number 3040301-46-7, is a small molecule designed to selectively target and degrade the human antigen R (HuR) protein, which plays a significant role in post-transcriptional regulation of gene expression. This compound is part of a class of molecules known as proteolysis-targeting chimeras (PROTACs), which harness the cellular ubiquitin-proteasome system to promote the degradation of specific proteins. HuR is implicated in various cellular processes, including mRNA stability and translation, and is associated with several diseases, including cancer. The characteristics of HuR degrader 2 include its ability to bind to HuR and an E3 ubiquitin ligase, facilitating the ubiquitination and subsequent degradation of HuR. This mechanism of action allows for the modulation of gene expression profiles, making HuR degrader 2 a potential therapeutic agent in conditions where HuR is dysregulated. Its development reflects a growing interest in targeted protein degradation as a strategy for drug discovery and therapeutic intervention.

<p>HuRdegrader 2 (Compound 3) is a molecular glue that targets and degrades the RNA-binding protein Hu antigen R (HuR), achieving 30% degradation at 0.1 μM. It inhibits the proliferation of Colo-205 cancer cells with an IC50 of ≤200 nM. HuRdegrader 2 also shows high affinity for cereblon with an HTRF ratio &lt; 0.02.</p>

CAS 3040301-46-7

HuR degrader 2

HuR degrader 2

Ref: TM-T210362