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CAS 3048196-52-4

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  • NU227326
    Targetmol
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    NU227326

    CAS:
    <p>NU227326 is a PROTAC degrader of indoleamine 2,3-dioxygenase 1 (IDO1) with a DC50 value of 4.5 nM. It effectively degrades IDO1 in U87 and GBM43 cells, with DC50 values of 7.1 nM and 11.8 nM, respectively. NU227326 exhibits favorable pharmacokinetic properties, with a plasma half-life of 5.7 hours and a brain tissue half-life of 11.8 hours. (Pink: ligand for target protein IDO1 ligand-1; Black: linker; Blue: ligand for E3 ligase Cereblon).</p>
    Formula:C53H61FN8O7
    Color and Shape:Solid
    Molecular weight:941.099

    Ref: TM-T205704