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CAS 3049076-98-1

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    YX-02-030

    CAS:
    <p>YX-02-030M is a PROTACMDM2 degrader. It inhibits the binding of MDM2 to p53 and VHL to HIF1α, with IC50 values of 63 nM and 1.35 μM, respectively. YX-02-030M binds to MDM2 and recruits the VHL E3 ubiquitin ligase to initiate MDM2 degradation, effectively killing p53 mutant or deficient triple-negative breast cancer (TNBC) cells.</p>
    Formula:C66H85Cl2N9O10S
    Molecular weight:1267.41

    Ref: TM-T208219