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CAS 305-96-4

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α-Methyl-m-tyrosine

Description:
α-Methyl-m-tyrosine, also known as metyrosine, is a non-proteinogenic amino acid that serves as a competitive inhibitor of the enzyme tyrosine hydroxylase, which is crucial in the biosynthesis of catecholamines such as dopamine, norepinephrine, and epinephrine. Its chemical structure features a methyl group attached to the alpha carbon of the m-tyrosine backbone, which alters its reactivity and biological function compared to standard amino acids. This compound is primarily utilized in clinical settings for the management of pheochromocytoma, a type of tumor that secretes excess catecholamines, thereby helping to control hypertension and other symptoms associated with this condition. α-Methyl-m-tyrosine is typically administered in its hydrochloride salt form, enhancing its solubility and stability. It is important to note that while it can effectively reduce catecholamine levels, it may also lead to side effects such as sedation and gastrointestinal disturbances. As with any medication, its use should be monitored by healthcare professionals to ensure safety and efficacy.
Formula:C10H13NO3
InChI:InChI=1/C10H13NO3/c1-10(11,9(13)14)6-7-3-2-4-8(12)5-7/h2-5,12H,6,11H2,1H3,(H,13,14)/t10-/m0/s1
InChI key:InChIKey=CAHPJJJZLQXPKS-UHFFFAOYSA-N
SMILES:C(C(C(O)=O)(C)N)C1=CC(O)=CC=C1
Synonyms:
  • (±)-α-Methyl-m-tyrosine
  • 2-Amino-3-(3-hydroxyphenyl)-2-methylpropanoic acid
  • 3-Hydroxy-α-methyl-3-phenylalanine
  • 3-Hydroxy-α-methylphenylalanine
  • 3-hydroxy-alpha-methyl-L-phenylalanine
  • <span class="text-smallcaps">DL</span>-α-Methyl-3-hydroxyphenylalanine
  • <span class="text-smallcaps">DL</span>-α-Methyl-m-tyrosine
  • Alpha-Methyl-M-Tyrosine
  • NSC 92520
  • Phenylalanine, 3-hydroxy-α-methyl-
  • See more synonyms
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Found 3 products.
  • 2-Amino-3-(3-hydroxyphenyl)-2-methylpropanoic acid
    Indagoo
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    2-Amino-3-(3-hydroxyphenyl)-2-methylpropanoic acid

    CAS:
    Formula:C10H13NO3
    Color and Shape:Solid
    Molecular weight:195.2151

    Ref: IN-DA0030DL

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  • α-Methyl-D,L-m-tyrosine
    Glentham
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    α-Methyl-D,L-m-tyrosine

    CAS:
    Molecular weight:195.22

    Ref: 7W-GC2928

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  • DL-α-Methyl-m-tyrosine
    Biosynth
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    DL-α-Methyl-m-tyrosine

    CAS:
    DL-alpha-Methyl-m-tyrosine (AMT) is a drug that is used to treat Parkinson's disease. It is an inhibitor of the uptake of dopamine and norepinephrine, which are neurotransmitters in the central nervous system. AMT blocks the action of a specific enzyme called aromatic L-amino acid decarboxylase, preventing the conversion of these neurotransmitters into their inactive metabolites. AMT also has been shown to be an antidepressant drug with stimulant properties. This may be due to its ability to inhibit uptake and release of monoamines in brain tissue.
    Formula:C10H13NO3
    Purity:Min. 95%
    Color and Shape:Powder
    Molecular weight:195.22 g/mol

    Ref: 3D-FM66494

    5g
    1,085.00€
    10g
    1,735.00€