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CAS 3050831-84-7

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  • ALK/PI3K/AKT-IN-1
    Targetmol
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    ALK/PI3K/AKT-IN-1

    CAS:
    <p>ALK/PI3K/AKT-IN-1 (Compound 45) effectively inhibits the proliferation of cancer cell lines A549, H1975, and PC9, with IC50 values of 0.44, 0.83, and 1.51 μM, respectively. This compound enhances the expression of p21 and p27, and decreases the activity of CDK2 and p-Rb, causing cell cycle arrest at the G1 phase. It suppresses the ALK/PI3K/AKT signaling pathway, promotes mitochondrial membrane potential depolarization, and induces apoptosis in A549 cells. Furthermore, ALK/PI3K/AKT-IN-1 inhibits the formation and growth of A549 cell spheres.</p>
    Formula:C25H20FN5O2S
    Color and Shape:Solid
    Molecular weight:473.522

    Ref: TM-T206308