CAS 3053413-58-1

DU-14 (PTP1B/TC-PTP PROTAC)

CAS: 3053413-58-1

DU-14 (PTP1B/TC-PTPPROTAC) is a potent and selective dual PROTAC degrader for PTP1B and TC-PTP, exhibiting IC50 values of 24.2 nM and 30.1 nM for the phosphatase activity of PTP1B and TC-PTP, respectively. It enhances IFN-γ signaling, promotes T cell activation, and possesses antitumor activity.

Formula: C₇₄H₈₅BrF₂N₉O₁₄PS

Molecular weight: 1505.46

Ref: TM-T203548