CAS 305372-78-5

CCT036477

CAS: 305372-78-5

Formula: C₂₁H₁₈ClN₃

Color and Shape: Solid

Molecular weight: 347.8407

Ref: IN-DA0030HH

CCT036477

CAS: 305372-78-5

Formula: C₂₁H₁₈ClN₃

Molecular weight: 347.84

Ref: 7W-GL4306

CCT036477

Controlled Product

CAS: 305372-78-5

Applications CCT036477 is an inhibitor of Wnt signaling. Studies show that CCT036477 does not alter β-catenin levels but blocks transcription at the β-catenin level. CCT036477 inhibited growth in several cancer cell lines and showed clear activity in vivo, blocking development of Zebrafish and Xenopus embryos and expression of Wnt target genes.
References Ewan, K. et al.: Cancer Res., 14, 5963 (2010);

Formula: C₂₁H₁₈ClN₃

Color and Shape: Neat

Molecular weight: 347.84

Ref: TR-C227900

Wnt Pathway Inhibitor XI, CCT036477

CAS: 305372-78-5

CCT036477 is a novel, potent inhibitor of the Wnt signaling pathway. It has been shown to inhibit tumor cell proliferation and induce apoptosis in cancer cells. CCT036477 inhibits protein transport by binding to the surface glycoprotein and blocking the receptor activity. This drug has also been shown to be effective against chemotherapeutic treatment in animal models, such as platinum-based chemotherapy, and to reduce the size of prostate cancer cells in vitro. Clinical trials are currently underway for CCT036477 to treat skin cancer and human osteosarcoma cell.

Formula: C₂₁H₁₈ClN₃

Purity: Min. 95%

Molecular weight: 347.84 g/mol

Ref: 3D-FMA37278

CCT036477

CAS: 305372-78-5

CCT036477 selectively inhibits Wnt/β-catenin signaling, reducing TCF/LEF transcriptional activity.

Formula: C₂₁H₁₈ClN₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 347.84

Ref: TM-T26968