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CAS 3056-17-5

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Stavudine

Description:
Stavudine, also known as d4T, is an antiretroviral medication primarily used in the treatment of HIV/AIDS. It belongs to the class of nucleoside reverse transcriptase inhibitors (NRTIs) and works by inhibiting the reverse transcriptase enzyme, which is crucial for viral replication. Stavudine is a synthetic analog of thymidine and is characterized by its ability to interfere with the viral life cycle, thereby reducing the viral load in infected individuals. The chemical formula of stavudine is C10H12N2O4, and it has a molecular weight of approximately 224.23 g/mol. It is typically administered orally and is known for its relatively low cost compared to other antiretroviral drugs. However, stavudine is associated with several side effects, including peripheral neuropathy and lactic acidosis, which necessitate careful monitoring during treatment. Due to its toxicity profile, it is often used in combination with other antiretroviral agents to enhance efficacy and minimize adverse effects.
Formula:C10H12N2O4
InChI:InChI=1/C10H14N2O4/c1-6-4-12(10(15)11-9(6)14)8-3-2-7(5-13)16-8/h2-3,6-8,13H,4-5H2,1H3,(H,11,14,15)
InChI key:InChIKey=XNKLLVCARDGLGL-JGVFFNPUSA-N
SMILES:O=C1N([C@@H]2O[C@H](CO)C=C2)C=C(C)C(=O)N1
Synonyms:
  • 1-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
  • 1-[5-(Hydroxymethyl)-2,5-Dihydrofuran-2-Yl]-5-Methyl-Hexahydropyrimidine-2,4-Dione
  • 2',3'-Didehydro-3'-Deoxythymidine
  • 2,4(1H,3H)-Pyrimidinedione, 1-[(2R,5S)-2,5-dihydro-5-(hydroxymethyl)-2-furanyl]-5-methyl-
  • 2′,3′-Didehydro-2′,3′-dideoxythymidine
  • 2′,3′-Didehydro-3′-deoxythymidine
  • 2′-Thymidinene, 3′-deoxy-
  • 3'-Deoxy-2',3'-Didehydrothymidine
  • 3'-Deoxythymidin-2'-Ene
  • 3′-Deoxy-2′,3′-didehydrothymidine
  • See more synonyms
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