CAS 30562-34-6: Geldanamycin

Description: Geldanamycin is a benzoquinone ansamycin antibiotic that is primarily known for its ability to inhibit the heat shock protein 90 (Hsp90), a molecular chaperone involved in the stabilization and function of numerous client proteins, including many involved in cancer progression. Its chemical structure features a complex bicyclic core with a quinone moiety, contributing to its biological activity. Geldanamycin exhibits a range of pharmacological effects, particularly in cancer therapy, as it can induce apoptosis in tumor cells by disrupting the function of oncogenic proteins. Additionally, it has shown potential in targeting various signaling pathways, making it a subject of interest in drug development. However, its clinical use is limited by toxicity and solubility issues, leading to the development of analogs with improved properties. As a natural product derived from the bacterium *Streptomyces hygroscopicus*, Geldanamycin serves as a valuable tool in both research and therapeutic contexts, particularly in the study of cancer biology and the development of Hsp90 inhibitors.

Formula: C₂₉H₄₀N₂O₉

InChI: InChI=1/C29H40N2O9/c1-15-11-19-25(34)20(14-21(32)27(19)39-7)31-28(35)16(2)9-8-10-22(37-5)26(40-29(30)36)18(4)13-17(3)24(33)23(12-15)38-6/h8-10,13-15,17,22-24,26,33H,11-12H2,1-7H3,(H2,30,36)(H,31,35)/b10-8-,16-9+,18-13+/t15-,17+,22+,23+,24-,26+/m1/s1

InChI key: InChIKey=QTQAWLPCGQOSGP-KSRBKZBZSA-N

SMILES: O=C(OC1C(=CC(C)C(O)C(OC)CC(C)CC=2C(=O)C(=CC(=O)C2OC)NC(=O)C(=CC=CC1OC)C)C)N

Synonyms:

• (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
• (8S,9S,12S,13R,14S,16R)-13-Hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
• 2-Azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9,13-dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-, 9-carbamate
• 2-Azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9-[(aminocarbonyl)oxy]-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-, [8S-(4E,6Z,8R*,9R*,10E,12R*,13S*,14R*,16S*)]-
• 2-Azabicyclo[16.3.1]docosane, geldanamycin deriv.
• Brn 1633093
• NSC 212518
• Nsc 122750
• U-29135
• [8S-(4E,6Z,8R*,9R*,10E,12R*,13S*,14R*,16S*)]-9-[(Aminocarbonyl)oxy]-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione
• Geldanamycin

Geldanamycin

CAS: 30562-34-6

• Formula: C₂₉H₄₀N₂O₉
• Purity: >95.0%(qNMR)
• Color and Shape: White to Yellow to Orange powder to crystal
• Molecular weight: 560.64

Geldanamycin, 98+%

CAS: 30562-34-6

Geldanamycin binds to and inhibits the cytosolic chaperone functions of heat shock protein 90 (HSP90). …

• Formula: C₂₉H₄₀N₂O₉
• Purity: 98+%
• Color and Shape: Powder or crystals or crystalline powder, Yellow
• Molecular weight: 560.64

Geldanamycin

CAS: 30562-34-6

• Formula: C₂₉H₄₀N₂O₉
• Purity: 100.0%
• Color and Shape: Orange amorphous solid
• Molecular weight: 560.0

Geldanamycin, Streptomyces hygroscopicus

CAS: 30562-34-6

• Purity: >95%
• Color and Shape: Solid
• Molecular weight: 560.644

[8S-(4E,6Z,8R*,9R*,10E,12R*,13S*,14R*,16S*)]-9-[(Aminocarbonyl)oxy]-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione

CAS: 30562-34-6

• Formula: C₂₉H₄₀N₂O₉
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 560.6359

Geldanamycin

CAS: 30562-34-6

• Purity: ≥98%
• Molecular weight: 560.64g/mol

Geldanamycin

CAS: 30562-34-6

• Formula: C₂₉H₄₀N₂O₉
• Purity: ≥ 98.0%
• Color and Shape: Yellow to orange powder
• Molecular weight: 560.64

Geldanamycin

CAS: 30562-34-6

• Formula: C₂₉H₄₀N₂O₉
• Molecular weight: 560.64

Geldanamycin

CAS: 30562-34-6

Geldanamycin, an HSP90 inhibitor (Kd: 1.2 μM), specifically disrupts glucocorticoid receptor (GR)/HSP association.

• Formula: C₂₉H₄₀N₂O₉
• Purity: 98.83% - 99.27%
• Color and Shape: Yellow To Orange Powder
• Molecular weight: 560.64

Geldanamycin

CAS: 30562-34-6

• Formula: C₂₉H₄₀N₂O₉
• Purity: By hplc: 99.66% (Typical Value in Batch COA)
• Color and Shape: yellow powder
• Molecular weight: 560.64g/mol

Geldanamycin

CAS: 30562-34-6

Applications Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines.It …

• Formula: C₂₉H₄₀N₂O₉
• Color and Shape: Neat
• Molecular weight: 560.64

Geldanamycin

CAS: 30562-34-6

Inhibits chaperone protein HSP90; anti-proliferative; antineoplastic

• Formula: C₂₉H₄₀N₂O₉
• Purity: Min. 95%
• Color and Shape: Yellow Powder
• Molecular weight: 560.64 g/mol

Geldanamycin (GLD) ex. Streptomyces Hygroscopicus, 98%

CAS: 30562-34-6

• Formula: C₂₉H₄₀N₂O₉
• Molecular weight: 560.64

Geldanamycin-FITC

CAS: 30562-34-6

• Formula: C₅₅H₆₃N₅O₁₃S
• Color and Shape: Neat
• Molecular weight: 1034.18