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CAS 3056647-52-7

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  • PROTAC c-Met degrader-1
    Targetmol
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    PROTAC c-Met degrader-1

    CAS:
    PROTACc-Met degrader-1 (Compound Met-DD4) is an orally effective PROTAC degrader targeting c-Met with a DC50 of 6.21 nM. It inhibits the proliferation of c-Met-addicted MKN-45 cells with an IC50 of 4.37 nM and causes cell cycle arrest in the G0/G1 phase. In a xenograft mouse model using MKN-45 cells, PROTACc-Met degrader-1 demonstrates antitumor activity.
    Formula:C45H41FN10O5
    Color and Shape:Solid
    Molecular weight:820.87

    Ref: TM-T201057