CAS 305841-29-6

Sagopilone

Description:

Sagopilone is a synthetic compound classified as a microtubule-stabilizing agent, primarily used in cancer therapy. It belongs to the class of epothilones, which are known for their ability to inhibit cancer cell proliferation by disrupting the normal function of microtubules, essential components of the cell's cytoskeleton. Sagopilone exhibits a mechanism of action similar to that of paclitaxel, but it is designed to overcome some of the resistance mechanisms that cancer cells develop against traditional taxanes. The compound has shown promise in preclinical and clinical studies for treating various types of tumors, including breast cancer. Its chemical structure features a complex ring system that contributes to its biological activity. Sagopilone is typically administered intravenously and has been evaluated for its pharmacokinetics, safety profile, and efficacy in clinical trials. As with many anticancer agents, its use may be associated with side effects, necessitating careful monitoring during treatment. Overall, sagopilone represents a significant advancement in the search for effective cancer therapies.

Formula: C₃₀H₄₁NO₆S

InChI: InChI=1S/C30H41NO6S/c1-7-9-20-27(34)17(2)10-8-13-30(6)25(37-30)15-22(19-11-12-23-21(14-19)31-18(3)38-23)36-26(33)16-24(32)29(4,5)28(20)35/h7,11-12,14,17,20,22,24-25,27,32,34H,1,8-10,13,15-16H2,2-6H3/t17-,20+,22-,24-,25-,27-,30+/m0/s1

InChI key: InChIKey=BFZKMNSQCNVFGM-UCEYFQQTSA-N

SMILES: C[C@@]12[C@@](O1)(C[C@H](OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](CC=C)[C@@H](O)[C@@H](C)CCC2)C=3C=C4C(=CC3)SC(C)=N4)[H]

Synonyms:

• 4,17-Dioxabicyclo[14.1.0]heptadecane-5,9-dione, 7,11-dihydroxy-8,8,12,16-tetramethyl-3-(2-methyl-5-benzothiazolyl)-10-(2-propenyl)-, (1S,3S,7S,10R,11S,12S,16R)-
• 4,17-Dioxabicyclo[14.1.0]heptadecane-5,9-dione, 7,11-dihydroxy-8,8,12,16-tetramethyl-3-(2-methyl-5-benzothiazolyl)-10-(2-propen-1-yl)-, (1S,3S,7S,10R,11S,12S,16R)-
• (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,12,16-tetramethyl-3-(2-methyl-5-benzothiazolyl)-10-(2-propen-1-yl)-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
• ZK-EPO
• Sagopilone

Sagopilone

CAS: 305841-29-6

Sagopilone is a Chinese analog that has shown potent anticancer activity. It is a cyclin-dependent kinase inhibitor that inhibits cancer cell growth by preventing the activation of proteins necessary for cell division. Sagopilone has been shown to be effective against a variety of human cancers, including tumors resistant to other inhibitors. This drug has also demonstrated apoptotic effects on cancer cells, inducing programmed cell death. Sagopilone may be used in combination with other anticancer drugs as it has been shown to enhance the efficacy of other kinase inhibitors. Sagopilone is excreted mainly through urine and has shown minimal toxicity in preclinical studies.

Formula: C₃₀H₄₁NO₆S

Purity: Min. 95%

Molecular weight: 543.7 g/mol

Ref: 3D-FMA84129

Sagopilone

CAS: 305841-29-6

Sagopilone: synthetic epothilone, inhibits cell division and induces apoptosis, effective in MDR tumors, not P-gp substrate.

Formula: C₃₀H₄₁NO₆S

Color and Shape: Solid

Molecular weight: 543.71

Ref: TM-T69480