CAS 3058636-12-4

Polθ-IN-5

Description:

Polθ-IN-5, identified by its CAS number 3058636-12-4, is a small molecule inhibitor specifically targeting the DNA polymerase theta (Polθ) enzyme. This compound is notable for its potential application in cancer therapy, particularly in tumors exhibiting homologous recombination deficiency. Polθ plays a crucial role in DNA repair processes, and its inhibition can lead to increased sensitivity of cancer cells to DNA-damaging agents. The characteristics of Polθ-IN-5 include its ability to selectively inhibit Polθ activity, thereby disrupting the repair of DNA double-strand breaks. This selectivity is significant as it minimizes effects on other DNA polymerases, potentially reducing off-target effects. Additionally, Polθ-IN-5 may exhibit favorable pharmacokinetic properties, enhancing its suitability for therapeutic use. Research into this compound is ongoing, focusing on its efficacy, safety profile, and mechanisms of action in various cancer models. Overall, Polθ-IN-5 represents a promising avenue for targeted cancer treatment strategies, particularly in precision oncology.

Formula: C₂₃H₁₈ClF₂N₇O₃S

Synonyms:

• [4,4′-Bipyridine]-3-carboxamide, 2′-chloro-N-[5-[[1-(difluoromethyl)-1H-pyrazol-4-yl]carbonyl]-5,6-dihydro-4H-pyrrolo[3,4-d]thiazol-2-yl]-5′-methoxy-6-methyl-
• Polθ-IN-5

Polθ-IN-5

CAS: 3058636-12-4

Polθ-IN-5 (Compound 139) is an inhibitor of DNA polymerase theta (Polθ) that exhibits antitumor activity.

Formula: C₂₃H₁₈ClF₂N₇O₃S

Color and Shape: Solid

Molecular weight: 545.95

Ref: TM-T200913