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CAS 3058911-16-0

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  • DeFer-2
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    DeFer-2

    CAS:
    DeFer-2 is a ferritin PROTAC degrader (Kd= 17.1 μM). It triggers the degradation of ferritin leading to the accumulation of free iron ions and an increase in ROS, which subsequently initiates caspase 3-GSDME mediated pyroptosis in cancer cells. DeFer-2 significantly inhibits tumor growth and extends the survival of mice with subcutaneous B16F10 tumors, and it is useful for melanoma research.
    Formula:C44H69N5O5S
    Color and Shape:Solid
    Molecular weight:780.11

    Ref: TM-T212081

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