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CAS 3059333-98-8

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  • SZU-B6
    Targetmol
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    SZU-B6

    CAS:
    SZU-B6, a PROTAC degrader, targets and degrades SIRT6 with DC50 values of 45 nM in SK-HEP-1 cells and 154 nM in Huh-7 cells. It inhibits the proliferation of SK-HEP-1 cells with an IC50 of 1.51 μM and suppresses colony formation in both SK-HEP-1 and Huh-7 cell lines. Additionally, SZU-B6 induces apoptosis in SK-HEP-1 cells and causes cell cycle arrest at the G2/M phase. It demonstrates anti-tumor activity in murine models.
    Formula:C29H32FN7O6
    Color and Shape:Solid
    Molecular weight:593.61

    Ref: TM-T200927

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