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CAS 306-03-6

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Hyoscyamine hydrobromide

Description:
Hyoscyamine hydrobromide is a tropane alkaloid derived from plants of the Solanaceae family, particularly from belladonna (Atropa belladonna) and other related species. It is a white to off-white crystalline powder that is soluble in water and alcohol, making it suitable for various pharmaceutical applications. Hyoscyamine acts primarily as an anticholinergic agent, blocking the action of acetylcholine at muscarinic receptors, which leads to effects such as reduced secretions, smooth muscle relaxation, and increased heart rate. It is commonly used in the treatment of gastrointestinal disorders, motion sickness, and as a pre-anesthetic medication. The substance has a relatively short half-life and is metabolized in the liver, with its effects typically lasting for several hours. Due to its potent pharmacological properties, hyoscyamine hydrobromide must be used with caution, as it can cause side effects such as dry mouth, blurred vision, and urinary retention. Its therapeutic use is often balanced against potential toxicity, particularly in sensitive populations.
Formula:C17H23NO3·BrH
InChI:InChI=1S/C17H23NO3.BrH/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12;/h2-6,13-16,19H,7-11H2,1H3;1H/t13-,14+,15+,16-;/m1./s1
InChI key:InChIKey=VZDNSFSBCMCXSK-PGQIENJJSA-N
SMILES:O(C([C@H](CO)C1=CC=CC=C1)=O)[C@@H]2C[C@]3(N(C)[C@@](C2)(CC3)[H])[H].Br
Synonyms:
  • Benzeneacetic acid, α-(hydroxymethyl)-, (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, hydrobromide (1:1), (αS)-
  • 8-methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate hydrobromide (1:1)
  • Daturine hydrobromide
  • (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl (2S)-3-hydroxy-2-phenylpropanoate hydrobromide
  • 1αH,5αH-Tropan-3α-ol, (-)-tropate (ester), hydrobromide
  • Hyoscyamine hydrobromide
  • Benzeneacetic acid, α-(hydroxymethyl)-, (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, hydrobromide, (αS)-
  • 8-methyl-8-azabicyclo[3.2.1]oct-3-yl (2S)-3-hydroxy-2-phenylpropanoate hydrobromide (1:1)
  • Benzeneacetic acid, α-(hydroxymethyl)-, 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, hydrobromide, [3(S)-endo]-
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