CAS 3062175-62-3

Benzenebutanoic acid, 4-[bis(2-chloroethyl)amino]-, 2-[4-[4-[[4-[[2-[(methylamino)carbonyl]phenyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]phenyl]-1-piperazinyl]ethyl ester

Formula: C₃₉H₄₅Cl₂F₃N₈O₃

Synonyms:

• Benzenebutanoic acid, 4-[bis(2-chloroethyl)amino]-, 2-[4-[4-[[4-[[2-[(methylamino)carbonyl]phenyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]phenyl]-1-piperazinyl]ethyl ester

FAK-IN-24

CAS: 3062175-62-3

FAK-IN-24 (Compound 9f) is a potent FAK inhibitor with an IC50 of 0.815 nM. It induces DNA damage and apoptosis, and exhibits activity against glioblastoma. FAK-IN-24 effectively inhibits proliferation of glioblastoma cell lines U87-MG (IC50= 15 nM) and U251 (IC50= 20 nM), and suppresses tumor growth in U87-MG xenograft models.

Formula: C₃₉H₄₅Cl₂F₃N₈O₃

Color and Shape: Solid

Molecular weight: 801.728

Ref: TM-T205467